USP9Y protein (Homo sapiens) - STRING network view

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USP9Y

ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...] (2555 aa)

Predicted Functional Partners:

EPN1

0.918

EPN2

0.918

EPN3

0.918

DDX3Y

0.891

UBC

0.876

UTY

0.860

KDM5D

0.816

DAZ1

0.814

GMPS

0.796

MIB1

0.770

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DAZ1	DDX3Y	ENSP00000384573	ENSP00000336725	deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	0.750
DAZ1	KDM5D	ENSP00000384573	ENSP00000444293	deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells	lysine (K)-specific demethylase 5D; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May play a role in spermatogenesis	0.562
DAZ1	USP9Y	ENSP00000384573	ENSP00000342812	deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.814
DAZ1	UTY	ENSP00000384573	ENSP00000328939	deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity)	0.715
DDX3Y	DAZ1	ENSP00000336725	ENSP00000384573	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	deleted in azoospermia 1; RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3’-UTR of mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ cells	0.750
DDX3Y	KDM5D	ENSP00000336725	ENSP00000444293	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	lysine (K)-specific demethylase 5D; Histone demethylase that specifically demethylates ’Lys- 4’ of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 ’Lys-9’, H3 ’Lys-27’, H3 ’Lys-36’, H3 ’Lys-79’ or H4 ’Lys-20’. Demethylates trimethylated and dimethylated but not monomethylated H3 ’Lys-4’. May play a role in spermatogenesis	0.754
DDX3Y	UBC	ENSP00000336725	ENSP00000344818	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ubiquitin C	0.947
DDX3Y	USP9Y	ENSP00000336725	ENSP00000342812	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.891
DDX3Y	UTY	ENSP00000336725	ENSP00000328939	DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked; Probable ATP-dependent RNA helicase. May play a role in spermatogenesis	ubiquitously transcribed tetratricopeptide repeat containing, Y-linked; Histone demethylase (By similarity)	0.816
EPN1	EPN3	ENSP00000406209	ENSP00000268933	epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis	epsin 3	0.613
EPN1	MIB1	ENSP00000406209	ENSP00000261537	epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis	mindbomb E3 ubiquitin protein ligase 1	0.485
EPN1	UBC	ENSP00000406209	ENSP00000344818	epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis	ubiquitin C	0.999
EPN1	USP9Y	ENSP00000406209	ENSP00000342812	epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.918
EPN2	MIB1	ENSP00000320543	ENSP00000261537	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	mindbomb E3 ubiquitin protein ligase 1	0.485
EPN2	UBC	ENSP00000320543	ENSP00000344818	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	ubiquitin C	0.945
EPN2	USP9Y	ENSP00000320543	ENSP00000342812	epsin 2; Plays a role in the formation of clathrin-coated invaginations and endocytosis	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.918
EPN3	EPN1	ENSP00000268933	ENSP00000406209	epsin 3	epsin 1; Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations (By similarity). Regulates receptor-mediated endocytosis	0.613
EPN3	MIB1	ENSP00000268933	ENSP00000261537	epsin 3	mindbomb E3 ubiquitin protein ligase 1	0.485
EPN3	UBC	ENSP00000268933	ENSP00000344818	epsin 3	ubiquitin C	0.748
EPN3	USP9Y	ENSP00000268933	ENSP00000342812	epsin 3	ubiquitin specific peptidase 9, Y-linked; May function as a ubiquitin-protein or polyubiquitin hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Monoubiquitination of SMAD4 hampers its ability to form a stable complex w [...]	0.918

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