Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SERPINA6 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 6; Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species (405 aa) | ||||||||||||
Predicted Functional Partners:
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 | SHBG | sex hormone-binding globulin (402 aa) |
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0.871 | ||||||||||
 | HNF4A | hepatocyte nuclear factor 4, alpha (474 aa) |
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0.852 | ||||||||||
 | POMC | proopiomelanocortin; ACTH stimulates the adrenal glands to release cortisol (267 aa) |
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0.815 | ||||||||||
 | SIRPG | signal-regulatory protein gamma; Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T- cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation (387 aa) |
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0.808 | ||||||||||
 | CRH | corticotropin releasing hormone; This hormone from hypothalamus regulates the release of corticotropin from pituitary gland (196 aa) |
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0.720 | ||||||||||
 | ALB | albumin (609 aa) |
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0.706 | |||||||||
 | KIAA1024 | KIAA1024 (916 aa) |
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0.664 | ||||||||||
 | HSD17B6 | hydroxysteroid (17-beta) dehydrogenase 6 homolog (mouse); NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3- alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is firs [...] (317 aa) |
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0.643 | |||||||||
 | HSD11B2 | hydroxysteroid (11-beta) dehydrogenase 2 (405 aa) |
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0.584 | ||||||||||
 | AVP | arginine vasopressin; Neurophysin 2 specifically binds vasopressin (164 aa) |
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0.566 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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