| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ADNP | CBX5 | ENSP00000342905 | ENSP00000209875 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | 0.704 |
| ADNP | EBNA1BP2 | ENSP00000342905 | ENSP00000407323 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | 0.903 |
| ADNP | GLRX | ENSP00000342905 | ENSP00000237858 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | glutaredoxin (thioltransferase); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins | 0.747 |
| ADNP | NFIA | ENSP00000342905 | ENSP00000360231 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | nuclear factor I/A; Recognizes and binds the palindromic sequence 5’- TTGGCNNNNNGCCAA-3’ present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication (By similarity) | 0.862 |
| ADNP | PHGDH | ENSP00000342905 | ENSP00000358417 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | phosphoglycerate dehydrogenase | 0.644 |
| ADNP | RRS1 | ENSP00000342905 | ENSP00000322396 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) | 0.644 |
| ADNP | SAP18 | ENSP00000342905 | ENSP00000371973 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.908 |
| ADNP | SEPT2 | ENSP00000342905 | ENSP00000353157 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | septin 2; Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongat [...] | 0.644 |
| ADNP | UBC | ENSP00000342905 | ENSP00000344818 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | ubiquitin C | 0.721 |
| ADNP | ZFP161 | ENSP00000342905 | ENSP00000349503 | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | zinc finger protein 161 homolog (mouse); Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters | 0.758 |
| CBX5 | ADNP | ENSP00000209875 | ENSP00000342905 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | 0.704 |
| CBX5 | SAP18 | ENSP00000209875 | ENSP00000371973 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.567 |
| CBX5 | UBC | ENSP00000209875 | ENSP00000344818 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | ubiquitin C | 0.853 |
| CBX5 | ZFP161 | ENSP00000209875 | ENSP00000349503 | chromobox homolog 5; Component of heterochromatin that recognizes and binds histone H3 tails methylated at ’Lys-9’ (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when ’Tyr-41’ of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins | zinc finger protein 161 homolog (mouse); Transcriptional activator of the dopamine transporter (DAT), binding it’s promoter at the consensus sequence 5’- CCTGCACAGTTCACGGA-3’. Binds to 5’-d(GCC)(n)-3’ trinucleotide repeats in promoter regions and acts as a repressor of the FMR1 gene. Transcriptional repressor of MYC and thymidine kinase promoters | 0.416 |
| EBNA1BP2 | ADNP | ENSP00000407323 | ENSP00000342905 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | 0.903 |
| EBNA1BP2 | RRS1 | ENSP00000407323 | ENSP00000322396 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae); Involved in ribosome biogenesis (By similarity) | 0.999 |
| EBNA1BP2 | SAP18 | ENSP00000407323 | ENSP00000371973 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | Sin3A-associated protein, 18kDa; Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent [...] | 0.547 |
| EBNA1BP2 | UBC | ENSP00000407323 | ENSP00000344818 | EBNA1 binding protein 2; Required for the processing of the 27S pre-rRNA (By similarity) | ubiquitin C | 0.891 |
| GLRX | ADNP | ENSP00000237858 | ENSP00000342905 | glutaredoxin (thioltransferase); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins | activity-dependent neuroprotector homeobox; Potential transcription factor. May mediate some of the neuroprotective peptide VIP-associated effects involving normal growth and cancer proliferation | 0.747 |
| GLRX | UBC | ENSP00000237858 | ENSP00000344818 | glutaredoxin (thioltransferase); Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins | ubiquitin C | 0.764 |
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