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CREBBP CREBBP GATA2 GATA2 JUN JUN NCOR1 NCOR1 LHX4 LHX4 ETS1 ETS1 POU1F1 POU1F1 GHRHR GHRHR PRL PRL PROP1 PROP1 TSHB TSHB
"POU1F1" - POU class 1 homeobox 1 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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POU1F1POU class 1 homeobox 1; Transcription factor involved in the specification of the lactotrope, somatotrope, and thyrotrope phenotypes in the developing anterior pituitary. Activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5’- TAAAT-3’ (317 aa)    
Predicted Functional Partners:
PRL
prolactin; Prolactin acts primarily on the mammary gland by promoting lactation (227 aa)
      score_image   score_image score_image   0.972
PROP1
PROP paired-like homeobox 1; Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes (226 aa)
            score_image   0.964
JUN
jun proto-oncogene; Transcription factor that recognizes and binds to the enhancer heptamer motif 5’-TGA[CG]TCA-3’. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation (331 aa)
        score_image   score_image   0.943
GHRHR
growth hormone releasing hormone receptor; Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion (423 aa)
            score_image   0.942
CREBBP
CREB binding protein; Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (2442 aa)
        score_image   score_image   0.929
ETS1
v-ets erythroblastosis virus E26 oncogene homolog 1 (avian); Transcription factor. Directly controls the expression of cytokine and chemokine genes in a wide variety of different cellular contexts. May control the differentiation, survival and proliferation of lymphoid cells. May also regulate angiogenesis through regulation of expression of genes controlling endothelial cell migration and invasion (485 aa)
        score_image   score_image   0.925
TSHB
thyroid stimulating hormone, beta; Indispensable for the control of thyroid structure and metabolism (138 aa)
            score_image   0.909
GATA2
GATA binding protein 2; Transcriptional activator which regulates endothelin-1 gene expression in endothelial cells. Binds to the consensus sequence 5’-AGATAG-3’ (480 aa)
        score_image   score_image   0.899
NCOR1
nuclear receptor corepressor 1; Mediates transcriptional repression by certain nuclear receptors. Part of a complex which promotes histone deacetylation and the formation of repressive chromatin structures which may impede the access of basal transcription factors (2440 aa)
        score_image   score_image   0.862
LHX4
LIM homeobox 4; May play a critical role in the development of respiratory control mechanisms and in the normal growth and maturation of the lung (By similarity) (390 aa)
            score_image   0.837
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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