Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | SERINC1 | serine incorporator 1; Enhances the incorporation of serine into phosphatidylserine and sphingolipids (By similarity) (453 aa) | ||||||||||||
Predicted Functional Partners:
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 | UBC | ubiquitin C (685 aa) |
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0.863 | |||||||||
 | ILF3 | interleukin enhancer binding factor 3, 90kDa (898 aa) |
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0.644 | ||||||||||
 | TMCO1 | transmembrane and coiled-coil domains 1 (188 aa) |
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0.644 | ||||||||||
 | IGF2R | insulin-like growth factor 2 receptor; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6- phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex. This receptor also binds IGF2. Acts as a positive regulator of T-cell coactivation, by binding DPP4 (2491 aa) |
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0.644 | ||||||||||
 | SAMM50 | sorting and assembly machinery component 50 homolog (S. cerevisiae); May be required for the assembly pathway of mitochondrial outer membrane proteins (By similarity) (469 aa) |
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0.644 | ||||||||||
 | CSMD1 | CUB and Sushi multiple domains 1; Potential suppressor of squamous cell carcinomas (3564 aa) |
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0.546 | ||||||||||
 | DNAJC13 | DnaJ (Hsp40) homolog, subfamily C, member 13 (2243 aa) |
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0.519 | ||||||||||
 | COG2 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa) |
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0.488 | ||||||||||
 | ALOX12B | arachidonate 12-lipoxygenase, 12R type; Converts arachidonic acid to 12R- hydroperoxyeicosatetraenoic acid (12R-HPETE) (701 aa) |
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0.408 | ||||||||||
 | LAPTM4A | lysosomal protein transmembrane 4 alpha; May function in the transport of nucleosides and/or nucleoside derivatives between the cytosol and the lumen of an intracellular membrane-bound compartment (By similarity) (233 aa) |
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0.407 | |||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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