node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BRIX1 | GRWD1 | ENSP00000338862 | ENSP00000253237 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | glutamate-rich WD repeat containing 1 | 0.984 |
BRIX1 | NAT10 | ENSP00000338862 | ENSP00000257829 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division | 0.868 |
BRIX1 | NOC2L | ENSP00000338862 | ENSP00000317992 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.993 |
BRIX1 | NOC3L | ENSP00000338862 | ENSP00000360412 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) | 0.985 |
BRIX1 | NOL10 | ENSP00000338862 | ENSP00000371101 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | nucleolar protein 10 | 0.882 |
BRIX1 | NOP2 | ENSP00000338862 | ENSP00000382392 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.994 |
BRIX1 | NSUN6 | ENSP00000338862 | ENSP00000366519 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.986 |
BRIX1 | POLR1B | ENSP00000338862 | ENSP00000263331 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.933 |
BRIX1 | PUS7L | ENSP00000338862 | ENSP00000343081 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | pseudouridylate synthase 7 homolog (S. cerevisiae)-like | 0.764 |
BRIX1 | WDR4 | ENSP00000338862 | ENSP00000328671 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.663 |
GRWD1 | BRIX1 | ENSP00000253237 | ENSP00000338862 | glutamate-rich WD repeat containing 1 | BRX1, biogenesis of ribosomes, homolog (S. cerevisiae); Required for biogenesis of the 60S ribosomal subunit | 0.984 |
GRWD1 | NAT10 | ENSP00000253237 | ENSP00000257829 | glutamate-rich WD repeat containing 1 | N-acetyltransferase 10 (GCN5-related); Has protein acetyltransferase activity in vitro. Can acetylate both histones and microtubules. Histone acetylation may regulate transcription and mitotic chromosome de-condensation. Activates telomerase activity by stimulating the transcription of TERT, and may also regulate telomerase function by affecting the balance of telomerase subunit assembly, disassembly, and localization. Acetylates alpha-tubulin, which may affect microtubule stability and cell division | 0.864 |
GRWD1 | NOC2L | ENSP00000253237 | ENSP00000317992 | glutamate-rich WD repeat containing 1 | nucleolar complex associated 2 homolog (S. cerevisiae); Acts as an inhibitor of histone acetyltransferase activity; prevents acetylation of all core histones by the EP300/p300 histone acetyltransferase at p53/TP53-regulated target promoters in a histone deacetylases (HDAC)-independent manner. Acts as a transcription corepressor of p53/TP53- and TP63-mediated transactivation of the p21/CDKN1A promoter. Involved in the regulation of p53/TP53-dependent apoptosis. Associates together with TP63 isoform TA*-gamma to the p21/CDKN1A promoter | 0.898 |
GRWD1 | NOC3L | ENSP00000253237 | ENSP00000360412 | glutamate-rich WD repeat containing 1 | nucleolar complex associated 3 homolog (S. cerevisiae); May be required for adipogenesis (By similarity) | 0.726 |
GRWD1 | NOL10 | ENSP00000253237 | ENSP00000371101 | glutamate-rich WD repeat containing 1 | nucleolar protein 10 | 0.835 |
GRWD1 | NOP2 | ENSP00000253237 | ENSP00000382392 | glutamate-rich WD repeat containing 1 | NOP2 nucleolar protein homolog (yeast); May play a role in the regulation of the cell cycle and the increased nucleolar activity that is associated with the cell proliferation. May act as ribosomal RNA methyltransferase | 0.969 |
GRWD1 | NSUN6 | ENSP00000253237 | ENSP00000366519 | glutamate-rich WD repeat containing 1 | NOP2/Sun domain family, member 6; May have S-adenosyl-L-methionine-dependent methyl- transferase activity (Potential) | 0.909 |
GRWD1 | POLR1B | ENSP00000253237 | ENSP00000263331 | glutamate-rich WD repeat containing 1 | polymerase (RNA) I polypeptide B, 128kDa; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity) | 0.953 |
GRWD1 | PUS7L | ENSP00000253237 | ENSP00000343081 | glutamate-rich WD repeat containing 1 | pseudouridylate synthase 7 homolog (S. cerevisiae)-like | 0.790 |
GRWD1 | WDR4 | ENSP00000253237 | ENSP00000328671 | glutamate-rich WD repeat containing 1 | WD repeat domain 4; Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational change of the catalytic subunit | 0.736 |