node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C1orf106 | TC2N | ENSP00000356311 | ENSP00000343199 | chromosome 1 open reading frame 106 | tandem C2 domains, nuclear | 0.411 |
CATSPER2 | SMEK1 | ENSP00000299989 | ENSP00000337125 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | 0.576 |
CATSPER2 | TC2N | ENSP00000299989 | ENSP00000343199 | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | tandem C2 domains, nuclear | 0.569 |
SCARA5 | TC2N | ENSP00000346990 | ENSP00000343199 | scavenger receptor class A, member 5 (putative); Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule c [...] | tandem C2 domains, nuclear | 0.668 |
SMEK1 | CATSPER2 | ENSP00000337125 | ENSP00000299989 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | 0.576 |
SMEK1 | TC2N | ENSP00000337125 | ENSP00000343199 | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | tandem C2 domains, nuclear | 0.710 |
SMEK2 | TC2N | ENSP00000339769 | ENSP00000343199 | SMEK homolog 2, suppressor of mek1 (Dictyostelium); Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | tandem C2 domains, nuclear | 0.489 |
SYT1 | TC2N | ENSP00000261205 | ENSP00000343199 | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | tandem C2 domains, nuclear | 0.585 |
TC2N | C1orf106 | ENSP00000343199 | ENSP00000356311 | tandem C2 domains, nuclear | chromosome 1 open reading frame 106 | 0.411 |
TC2N | CATSPER2 | ENSP00000343199 | ENSP00000299989 | tandem C2 domains, nuclear | cation channel, sperm associated 2; Voltage-gated calcium channel that plays a central role in calcium-dependent physiological responses essential for successful fertilization, such as sperm hyperactivation, acrosome reaction and chemotaxis towards the oocyte. Activated by extracellular progesterone and prostaglandins following the sequence- progesterone > PGF1-alpha = PGE1 > PGA1 > PGE2 >> PGD2. The primary effect of progesterone activation is to shift voltage dependence towards more physiological, negative membrane potentials; it is not mediated by metabotropic receptors and second m [...] | 0.569 |
TC2N | SCARA5 | ENSP00000343199 | ENSP00000346990 | tandem C2 domains, nuclear | scavenger receptor class A, member 5 (putative); Ferritin receptor that mediates non-transferrin- dependent delivery of iron. Mediates cellular uptake of ferritin- bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type- specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule c [...] | 0.668 |
TC2N | SMEK1 | ENSP00000343199 | ENSP00000337125 | tandem C2 domains, nuclear | SMEK homolog 1, suppressor of mek1 (Dictyostelium) | 0.710 |
TC2N | SMEK2 | ENSP00000343199 | ENSP00000339769 | tandem C2 domains, nuclear | SMEK homolog 2, suppressor of mek1 (Dictyostelium); Regulatory subunit of serine/threonine-protein phosphatase 4 (PP4). May regulate the activity of PPP4C at centrosomal microtubule organizing centers | 0.489 |
TC2N | SYT1 | ENSP00000343199 | ENSP00000261205 | tandem C2 domains, nuclear | synaptotagmin I; May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2 | 0.585 |