Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
|
Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C21orf7 | chromosome 21 open reading frame 7 (242 aa) | ||||||||||||
Predicted Functional Partners:
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 | PRDM15 | PR domain containing 15; May be involved in transcriptional regulation (1507 aa) |
 |
0.806 | ||||||||||
 | TAB3 | TGF-beta activated kinase 1/MAP3K7 binding protein 3; Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator of MAP3K7 activation, respectively in the IL1 and TNF signaling pathways. Plays a role in activation of NF-kappa-B and AP1 transcription factor. Isoform 2 may be an oncogenic factor (712 aa) |
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0.788 | ||||||||||
 | BCL2 | B-cell CLL/lymphoma 2; Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1) (239 aa) |
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0.785 | ||||||||||
 | YBEY | ybeY metallopeptidase (putative) (167 aa) |
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0.593 | ||||||||||
 | PRRT1 | proline-rich transmembrane protein 1 (306 aa) |
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0.589 | ||||||||||
 | LCA5 | Leber congenital amaurosis 5; Might be involved in minus end-directed microtubule transport (697 aa) |
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0.584 | ||||||||||
 | SETD4 | SET domain containing 4 (440 aa) |
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0.507 | ||||||||||
 | C21orf58 | chromosome 21 open reading frame 58 (322 aa) |
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0.505 | ||||||||||
 | DNAJC28 | DnaJ (Hsp40) homolog, subfamily C, member 28; May have a role in protein folding or as a chaperone (388 aa) |
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0.485 | ||||||||||
 | C14orf1 | chromosome 14 open reading frame 1 (140 aa) |
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0.483 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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