Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | C9orf171 | chromosome 9 open reading frame 171 (320 aa) | ||||||||||||
Predicted Functional Partners:
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 | CCDC67 | coiled-coil domain containing 67 (604 aa) |
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0.700 | ||||||||||
 | TTC28 | tetratricopeptide repeat domain 28 (2481 aa) |
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0.583 | ||||||||||
 | FAM190A | family with sequence similarity 190, member A (900 aa) |
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0.582 | ||||||||||
 | COL6A6 | collagen, type VI, alpha 6; Collagen VI acts as a cell-binding protein (By similarity) (2263 aa) |
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0.568 | ||||||||||
 | MTMR8 | myotubularin related protein 8; Phosphatase that acts on lipids with a phosphoinositol headgroup (Probable) (704 aa) |
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0.511 | ||||||||||
 | SLC25A43 | solute carrier family 25, member 43 (341 aa) |
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0.472 | ||||||||||
 | UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity) (1416 aa) |
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0.463 | ||||||||||
 | MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) (552 aa) |
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0.450 | ||||||||||
 | FAM65B | family with sequence similarity 65, member B; Isoform 2 play a role in promoting myogenic cell differentiation, cytoskeletal rearrangement and filopodia formation (1068 aa) |
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0.450 | ||||||||||
 | HSD17B11 | hydroxysteroid (17-beta) dehydrogenase 11; Can convert androstan-3-alpha,17-beta-diol (3-alpha- diol) to androsterone in vitro, suggesting that it may participate in androgen metabolism during steroidogenesis. May act by metabolizing compounds that stimulate steroid synthesis and/or by generating metabolites that inhibit it. Has no activity toward DHEA (dehydroepiandrosterone), or A-dione (4-androste-3,17-dione), and only a slight activity toward testosterone to A-dione. Tumor- associated antigen in cutaneous T-cell lymphoma (300 aa) |
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0.416 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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