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MAVS MAVS ATG16L2 ATG16L2 GABARAPL1 GABARAPL1 ATG12 ATG12 ATG5 ATG5 ATG3 ATG3 WDFY3 WDFY3 ATG7 ATG7 ATG10 ATG10 ATG16L1 ATG16L1 GABARAPL2 GABARAPL2
"ATG5" - autophagy related 5 in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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white nodes:
second shell of interactors
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Predicted Interactions
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ATG5autophagy related 5; Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed (By similarity) (275 aa)    
Predicted Functional Partners:
ATG12
autophagy related 12; Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through an ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct associ [...] (140 aa)
        score_image score_image score_image   0.999
ATG16L1
autophagy related 16-like 1 (S. cerevisiae) (607 aa)
        score_image score_image score_image   0.999
ATG3
autophagy related 3; E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1- E2 complex with ATG3 (314 aa)
        score_image   score_image   0.997
ATG16L2
autophagy related 16-like 2 (S. cerevisiae); May play a role in autophagy (By similarity) (619 aa)
        score_image score_image score_image   0.995
MAVS
mitochondrial antiviral signaling protein (540 aa)
        score_image score_image score_image   0.993
ATG10
autophagy related 10; E2-like enzyme involved in autophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for autophagy. Likely serves as an ATG5-recognition molecule. Not involved in ATG12 conjugation to ATG3 (By similarity) (220 aa)
        score_image score_image score_image   0.986
WDFY3
WD repeat and FYVE domain containing 3 (3526 aa)
        score_image   score_image   0.985
GABARAPL1
GABA(A) receptor-associated protein like 1; Increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles (117 aa)
        score_image   score_image   0.974
GABARAPL2
GABA(A) receptor-associated protein-like 2; Involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (By similarity) (117 aa)
        score_image   score_image   0.974
ATG7
autophagy related 7; Functions as an E1 enzyme essential for multisubstrates such as ATG8-like proteins and ATG12. Forms intermediate conjugates with ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A). PE-conjugation to ATG8-like proteins is essential for autophagy. Also acts as an E1 enzyme for ATG12 conjugation to ATG5 and ATG3 (By similarity) (703 aa)
        score_image   score_image   0.973
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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