node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BTRC | SERPINB4 | ENSP00000359206 | ENSP00000343445 | beta-transducin repeat containing E3 ubiquitin protein ligase; Substrate recognition component of a SCF (SKP1-CUL1-F- box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of N [...] | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.755 |
CDH1 | MAPK8 | ENSP00000261769 | ENSP00000353483 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | mitogen-activated protein kinase 8; Serine/threonine-protein kinase involved in various processes such as cell proliferation, differentiation, migration, transformation and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK8/JNK1. In turn, MAPK8/JNK1 phosphorylates a number of transcription factors, primarily components of AP-1 such as JU [...] | 0.459 |
CDH1 | NR2F1 | ENSP00000261769 | ENSP00000325819 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | nuclear receptor subfamily 2, group F, member 1; Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5’-AGGTCA-3’ motif. Represses transcriptional activity of LHCG | 0.671 |
CDH1 | NR2F2 | ENSP00000261769 | ENSP00000377721 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | nuclear receptor subfamily 2, group F, member 2; Ligand-activated transcription factor. Activated by high concentrations of 9-cis-retinoic acid and all-trans-retinoic acid, but not by dexamethasone, cortisol or progesterone (in vitro). Regulation of the apolipoprotein A-I gene transcription. Binds to DNA site A | 0.702 |
CDH1 | PRDM10 | ENSP00000261769 | ENSP00000351686 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | PR domain containing 10 | 0.700 |
CDH1 | SERPINB4 | ENSP00000261769 | ENSP00000343445 | cadherin 1, type 1, E-cadherin (epithelial); Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells. Has a potent invasive suppressor role. It is a ligand for integrin alpha-E/beta-7 | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.815 |
CMA1 | CTSS | ENSP00000250378 | ENSP00000357981 | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.563 |
CMA1 | PRDM10 | ENSP00000250378 | ENSP00000351686 | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | PR domain containing 10 | 0.450 |
CMA1 | SERPINB4 | ENSP00000250378 | ENSP00000343445 | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.530 |
CTRL | CTSS | ENSP00000458537 | ENSP00000357981 | chymotrypsin-like | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.562 |
CTRL | PRDM10 | ENSP00000458537 | ENSP00000351686 | chymotrypsin-like | PR domain containing 10 | 0.645 |
CTRL | SERPINB4 | ENSP00000458537 | ENSP00000343445 | chymotrypsin-like | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.552 |
CTSG | CTSS | ENSP00000216336 | ENSP00000357981 | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | 0.700 |
CTSG | PRDM10 | ENSP00000216336 | ENSP00000351686 | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | PR domain containing 10 | 0.570 |
CTSG | SERPINB4 | ENSP00000216336 | ENSP00000343445 | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.992 |
CTSS | CMA1 | ENSP00000357981 | ENSP00000250378 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | chymase 1, mast cell; Major secreted protease of mast cells with suspected roles in vasoactive peptide generation, extracellular matrix degradation, and regulation of gland secretion | 0.563 |
CTSS | CTRL | ENSP00000357981 | ENSP00000458537 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | chymotrypsin-like | 0.562 |
CTSS | CTSG | ENSP00000357981 | ENSP00000216336 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | cathepsin G; Serine protease with trypsin- and chymotrypsin-like specificity. Cleaves complement C3. Has antibacterial activity against the Gram-negative bacterium P.aeruginosa, antibacterial activity is inhibited by LPS from P.aeruginosa, Z-Gly-Leu-Phe- CH2Cl and phenylmethylsulfonyl fluoride | 0.700 |
CTSS | PRDM10 | ENSP00000357981 | ENSP00000351686 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | PR domain containing 10 | 0.535 |
CTSS | SERPINB4 | ENSP00000357981 | ENSP00000343445 | cathepsin S; Thiol protease. Key protease responsible for the removal of the invariant chain from MHC class II molecules. The bond- specificity of this proteinase is in part similar to the specificities of cathepsin L and cathepsin N | serpin peptidase inhibitor, clade B (ovalbumin), member 4; May act as a protease inhibitor to modulate the host immune response against tumor cells | 0.954 |