| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CCL17 | TPSAB1 | ENSP00000219244 | ENSP00000343577 | chemokine (C-C motif) ligand 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.485 |
| CPA3 | TPSAB1 | ENSP00000296046 | ENSP00000343577 | carboxypeptidase A3 (mast cell) | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.627 |
| CPA4 | TPSAB1 | ENSP00000222482 | ENSP00000343577 | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.426 |
| CTSC | KRT9 | ENSP00000227266 | ENSP00000246662 | cathepsin C | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | 0.517 |
| CTSC | TPSAB1 | ENSP00000227266 | ENSP00000343577 | cathepsin C | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.609 |
| KRT9 | CTSC | ENSP00000246662 | ENSP00000227266 | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | cathepsin C | 0.517 |
| KRT9 | TPSAB1 | ENSP00000246662 | ENSP00000343577 | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.472 |
| LGALS3 | TPSAB1 | ENSP00000254301 | ENSP00000343577 | lectin, galactoside-binding, soluble, 3; Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus- acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.814 |
| RAC1 | RAC2 | ENSP00000348461 | ENSP00000249071 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.901 |
| RAC1 | TPSAB1 | ENSP00000348461 | ENSP00000343577 | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.547 |
| RAC2 | RAC1 | ENSP00000249071 | ENSP00000348461 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1); Plasma membrane-associated small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as secretory processes, phagocytosis of apoptotic cells, epithelial cell polarization and growth-factor induced formation of membrane ruffles. Rac1 p21/rho GDI heterodimer is the active component of the cytosolic factor sigma 1, which is involved in stimulation of the NADPH oxidase activity in ma [...] | 0.901 |
| RAC2 | RAC3 | ENSP00000249071 | ENSP00000304283 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | 0.901 |
| RAC2 | TPSAB1 | ENSP00000249071 | ENSP00000343577 | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.696 |
| RAC3 | RAC2 | ENSP00000304283 | ENSP00000249071 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.901 |
| RAC3 | TPSAB1 | ENSP00000304283 | ENSP00000343577 | ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3); Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as cell spreading and the formation of actin-based protusions including lamellipodia and membrane ruffles | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | 0.547 |
| TPSAB1 | CCL17 | ENSP00000343577 | ENSP00000219244 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | chemokine (C-C motif) ligand 17; Chemotactic factor for T-lymphocytes but not monocytes or granulocytes. May play a role in T-cell development in thymus and in trafficking and activation of mature T-cells. Binds to CCR4 | 0.485 |
| TPSAB1 | CPA3 | ENSP00000343577 | ENSP00000296046 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | carboxypeptidase A3 (mast cell) | 0.627 |
| TPSAB1 | CPA4 | ENSP00000343577 | ENSP00000222482 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | carboxypeptidase A4; Metalloprotease that could be involved in the histone hyperacetylation pathway | 0.426 |
| TPSAB1 | CTSC | ENSP00000343577 | ENSP00000227266 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | cathepsin C | 0.609 |
| TPSAB1 | KRT9 | ENSP00000343577 | ENSP00000246662 | tryptase alpha/beta 1; Tryptase is the major neutral protease present in mast cells and is secreted upon the coupled activation-degranulation response of this cell type. Has an immunoprotective role during bacterial infection. Required to efficiently combat K.pneumoniae infection (By similarity) | keratin 9; May serve an important special function either in the mature palmar and plantar skin tissue or in the morphogenetic program of the formation of these tissues. Plays a role in keratin filament assembly | 0.472 |
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