GJA4 protein (Homo sapiens) - STRING network view

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GJA4

gap junction protein, alpha 4, 37kDa (333 aa)

Predicted Functional Partners:

NOS3

0.842

SEMA3D

0.773

AGT

0.722

PIK3CA

0.690

SGSM3

0.683

TAF2

0.667

IFNG

0.666

F2

0.625

KIAA1432

0.607

TNF

0.606

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGT	F2	ENSP00000355627	ENSP00000308541	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	0.946
AGT	GJA4	ENSP00000355627	ENSP00000343676	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	gap junction protein, alpha 4, 37kDa	0.722
AGT	NOS3	ENSP00000355627	ENSP00000297494	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity)	0.937
AGT	PIK3CA	ENSP00000355627	ENSP00000263967	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to variou [...]	0.902
AGT	TNF	ENSP00000355627	ENSP00000398698	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	tumor necrosis factor	0.599
F2	AGT	ENSP00000308541	ENSP00000355627	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.946
F2	GJA4	ENSP00000308541	ENSP00000343676	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	gap junction protein, alpha 4, 37kDa	0.625
F2	NOS3	ENSP00000308541	ENSP00000297494	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity)	0.593
F2	TNF	ENSP00000308541	ENSP00000398698	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	tumor necrosis factor	0.675
GJA4	AGT	ENSP00000343676	ENSP00000355627	gap junction protein, alpha 4, 37kDa	angiotensinogen (serpin peptidase inhibitor, clade A, member 8); Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis	0.722
GJA4	F2	ENSP00000343676	ENSP00000308541	gap junction protein, alpha 4, 37kDa	coagulation factor II (thrombin); Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing	0.625
GJA4	IFNG	ENSP00000343676	ENSP00000229135	gap junction protein, alpha 4, 37kDa	interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity)	0.666
GJA4	KIAA1432	ENSP00000343676	ENSP00000416696	gap junction protein, alpha 4, 37kDa	KIAA1432	0.607
GJA4	NOS3	ENSP00000343676	ENSP00000297494	gap junction protein, alpha 4, 37kDa	nitric oxide synthase 3 (endothelial cell); Produces nitric oxide (NO) (By similarity)	0.842
GJA4	PIK3CA	ENSP00000343676	ENSP00000263967	gap junction protein, alpha 4, 37kDa	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha; Phosphoinositide-3-kinase (PI3K) that phosphorylates PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4- phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5- bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Participates in cellular signaling in response to variou [...]	0.690
GJA4	SEMA3D	ENSP00000343676	ENSP00000284136	gap junction protein, alpha 4, 37kDa	sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D; Induces the collapse and paralysis of neuronal growth cones. Could potentially act as repulsive cues toward specific neuronal populations. Binds to neuropilin (By similarity)	0.773
GJA4	SGSM3	ENSP00000343676	ENSP00000248929	gap junction protein, alpha 4, 37kDa	small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells	0.683
GJA4	TAF2	ENSP00000343676	ENSP00000367406	gap junction protein, alpha 4, 37kDa	TAF2 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 150kDa; Transcription factor TFIID is one of the general factors required for accurate and regulated initiation by RNA polymerase II. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. It requires core promoter-specific cofactors for productive transcription stimulation. TAF2 stabilizes TFIID binding to core promoter	0.667
GJA4	TNF	ENSP00000343676	ENSP00000398698	gap junction protein, alpha 4, 37kDa	tumor necrosis factor	0.606
IFNG	GJA4	ENSP00000229135	ENSP00000343676	interferon, gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity)	gap junction protein, alpha 4, 37kDa	0.666

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