node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATRAID | FAM215A | ENSP00000369518 | ENSP00000464743 | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | family with sequence similarity 215, member A (non-protein coding) | 0.720 |
ATRAID | MAGEH1 | ENSP00000369518 | ENSP00000343706 | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | melanoma antigen family H, 1 | 0.736 |
C11orf40 | MAGEH1 | ENSP00000302918 | ENSP00000343706 | chromosome 11 open reading frame 40 | melanoma antigen family H, 1 | 0.634 |
EID3 | MAGEH1 | ENSP00000435619 | ENSP00000343706 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | melanoma antigen family H, 1 | 0.829 |
EID3 | NSMCE1 | ENSP00000435619 | ENSP00000355077 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | non-SMC element 1 homolog (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro [...] | 0.996 |
EID3 | NSMCE4A | ENSP00000435619 | ENSP00000358019 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.902 |
FAM215A | ATRAID | ENSP00000464743 | ENSP00000369518 | family with sequence similarity 215, member A (non-protein coding) | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | 0.720 |
FAM215A | MAGEH1 | ENSP00000464743 | ENSP00000343706 | family with sequence similarity 215, member A (non-protein coding) | melanoma antigen family H, 1 | 0.725 |
MAGEH1 | ATRAID | ENSP00000343706 | ENSP00000369518 | melanoma antigen family H, 1 | all-trans retinoic acid-induced differentiation factor; Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway | 0.736 |
MAGEH1 | C11orf40 | ENSP00000343706 | ENSP00000302918 | melanoma antigen family H, 1 | chromosome 11 open reading frame 40 | 0.634 |
MAGEH1 | EID3 | ENSP00000343706 | ENSP00000435619 | melanoma antigen family H, 1 | EP300 interacting inhibitor of differentiation 3; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components | 0.829 |
MAGEH1 | FAM215A | ENSP00000343706 | ENSP00000464743 | melanoma antigen family H, 1 | family with sequence similarity 215, member A (non-protein coding) | 0.725 |
MAGEH1 | MSX1 | ENSP00000343706 | ENSP00000372170 | melanoma antigen family H, 1 | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | 0.710 |
MAGEH1 | NGF | ENSP00000343706 | ENSP00000358525 | melanoma antigen family H, 1 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | 0.941 |
MAGEH1 | NGFR | ENSP00000343706 | ENSP00000172229 | melanoma antigen family H, 1 | nerve growth factor receptor; Plays a role in the regulation of the translocation of GLUT4 to the cell surface in adipocytes and skeletal muscle cells in response to insulin, probably by regulating RAB31 activity, and thereby contributes to the regulation of insulin-dependent glucose uptake (By similarity). Low affinity receptor which can bind to NGF, BDNF, NT-3, and NT-4. Can mediate cell survival as well as cell death of neural cells | 0.991 |
MAGEH1 | NSMCE1 | ENSP00000343706 | ENSP00000355077 | melanoma antigen family H, 1 | non-SMC element 1 homolog (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Has in vitro [...] | 0.682 |
MAGEH1 | NSMCE4A | ENSP00000343706 | ENSP00000358019 | melanoma antigen family H, 1 | non-SMC element 4 homolog A (S. cerevisiae); Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT- associated PML bodies (APBs). Is involved [...] | 0.829 |
MAGEH1 | SORT1 | ENSP00000343706 | ENSP00000256637 | melanoma antigen family H, 1 | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.900 |
MSX1 | MAGEH1 | ENSP00000372170 | ENSP00000343706 | msh homeobox 1; Acts as a transcriptional repressor. May play a role in limb-pattern formation. Acts in cranofacial development and specifically in odontogenesis. Expression in the developing nail bed mesenchyme is important for nail plate thickness and integrity | melanoma antigen family H, 1 | 0.710 |
NGF | MAGEH1 | ENSP00000358525 | ENSP00000343706 | nerve growth factor (beta polypeptide); Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades through those receptor tyrosine kinase to regulate neuronal proliferation, differentiation and survival | melanoma antigen family H, 1 | 0.941 |