node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACTN1 | ACTN2 | ENSP00000377941 | ENSP00000355537 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
ACTN1 | MYH14 | ENSP00000377941 | ENSP00000262269 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | myosin, heavy chain 14, non-muscle | 0.630 |
ACTN1 | TTN | ENSP00000377941 | ENSP00000343764 | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | titin | 0.976 |
ACTN2 | ACTN1 | ENSP00000355537 | ENSP00000377941 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.999 |
ACTN2 | MYBPC3 | ENSP00000355537 | ENSP00000442795 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | 0.934 |
ACTN2 | MYH14 | ENSP00000355537 | ENSP00000262269 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | myosin, heavy chain 14, non-muscle | 0.657 |
ACTN2 | NEB | ENSP00000355537 | ENSP00000380505 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | nebulin | 0.936 |
ACTN2 | TCAP | ENSP00000355537 | ENSP00000312624 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk | 0.959 |
ACTN2 | TTN | ENSP00000355537 | ENSP00000343764 | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | titin | 0.998 |
CAPN3 | MYH14 | ENSP00000380349 | ENSP00000262269 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | myosin, heavy chain 14, non-muscle | 0.514 |
CAPN3 | NEB | ENSP00000380349 | ENSP00000380505 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | nebulin | 0.503 |
CAPN3 | OBSCN | ENSP00000380349 | ENSP00000455507 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF | 0.483 |
CAPN3 | TCAP | ENSP00000380349 | ENSP00000312624 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk | 0.634 |
CAPN3 | TRIM63 | ENSP00000380349 | ENSP00000363390 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...] | 0.499 |
CAPN3 | TTN | ENSP00000380349 | ENSP00000343764 | calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease | titin | 0.998 |
MYBPC3 | ACTN2 | ENSP00000442795 | ENSP00000355537 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein | 0.934 |
MYBPC3 | MYH14 | ENSP00000442795 | ENSP00000262269 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | myosin, heavy chain 14, non-muscle | 0.979 |
MYBPC3 | NEB | ENSP00000442795 | ENSP00000380505 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | nebulin | 0.932 |
MYBPC3 | TCAP | ENSP00000442795 | ENSP00000312624 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk | 0.946 |
MYBPC3 | TRIM63 | ENSP00000442795 | ENSP00000363390 | myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role | tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...] | 0.688 |