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STRINGSTRING
CAPN3 CAPN3 OBSCN OBSCN OBSL1 OBSL1 MYH14 MYH14 TTN TTN TRIM63 TRIM63 NEB NEB TCAP TCAP ACTN1 ACTN1 ACTN2 ACTN2 MYBPC3 MYBPC3
"TTN" - titin in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
TTNtitin (33423 aa)    
Predicted Functional Partners:
TCAP
titin-cap; Muscle assembly regulating factor. Mediates the antiparallel assembly of titin (TTN) molecules at the sarcomeric Z-disk (167 aa)
      score_image score_image score_image score_image   0.999
NEB
nebulin (8525 aa)
      score_image score_image score_image score_image   0.999
ACTN2
actinin, alpha 2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (894 aa)
      score_image score_image score_image score_image   0.998
CAPN3
calpain 3, (p94); Calcium-regulated non-lysosomal thiol-protease (821 aa)
        score_image   score_image   0.998
TRIM63
tripartite motif containing 63, E3 ubiquitin protein ligase; E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertroph [...] (353 aa)
      score_image score_image   score_image   0.994
OBSL1
obscurin-like 1; Regulates CUL7-FBXW8-containing ubiquitin ligase complex, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Localizes CUL7 to the Golgi apparatus in neurons (1896 aa)
      score_image score_image   score_image score_image 0.986
MYBPC3
myosin binding protein C, cardiac; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role (1274 aa)
      score_image score_image score_image score_image score_image 0.985
OBSCN
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF (8678 aa)
      score_image score_image   score_image score_image 0.977
ACTN1
actinin, alpha 1; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (914 aa)
      score_image score_image   score_image   0.976
MYH14
myosin, heavy chain 14, non-muscle (2036 aa)
      score_image     score_image   0.975
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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