| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTC1 | KLHL17 | ENSP00000290378 | ENSP00000343930 | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.596 |
| FEZF1 | KLHL17 | ENSP00000411145 | ENSP00000343930 | FEZ family zinc finger 1; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity) | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.482 |
| FEZF2 | KLHL17 | ENSP00000283268 | ENSP00000343930 | FEZ family zinc finger 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity) | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.482 |
| GFI1 | KLHL17 | ENSP00000294702 | ENSP00000343930 | growth factor independent 1 transcription repressor; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5’-TAAATCAC[AT]GCA-3’ in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required fo [...] | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.482 |
| GFI1B | KLHL17 | ENSP00000344782 | ENSP00000343930 | growth factor independent 1B transcription repressor; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling path [...] | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.482 |
| GRIK2 | KLHL17 | ENSP00000397026 | ENSP00000343930 | glutamate receptor, ionotropic, kainate 2 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.903 |
| HEATR8 | KLHL17 | ENSP00000396622 | ENSP00000343930 | HEAT repeat containing 8 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.471 |
| KLHL17 | ACTC1 | ENSP00000343930 | ENSP00000290378 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | actin, alpha, cardiac muscle 1; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | 0.596 |
| KLHL17 | FEZF1 | ENSP00000343930 | ENSP00000411145 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | FEZ family zinc finger 1; Transcription repressor. Involved in the axonal projection and proper termination of olfactory sensory neurons (OSN). Plays a role in rostro-caudal patterning of the diencephalon and in prethalamic formation. Expression is required in OSN to cell-autonomously regulate OSN axon projections. Regulates non-cell-autonomously the layer formation of the olfactory bulb development and the interneurons. May be required for correct rostral migration of the interneuron progenitors (By similarity) | 0.482 |
| KLHL17 | FEZF2 | ENSP00000343930 | ENSP00000283268 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | FEZ family zinc finger 2; Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity) | 0.482 |
| KLHL17 | GFI1 | ENSP00000343930 | ENSP00000294702 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | growth factor independent 1 transcription repressor; Transcription repressor essential for hematopoiesis. Functions in a cell-context and development-specific manner. Binds to 5’-TAAATCAC[AT]GCA-3’ in the promoter region of a large number of genes. Component of several complexes, including the EHMT2- GFI1-HDAC1, AJUBA-GFI1-HDAC1 and RCOR-GFI-KDM1A-HDAC complexes, that suppress, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development. Regulates neutrophil differentiation, promotes proliferation of lymphoid cells, and is required fo [...] | 0.482 |
| KLHL17 | GFI1B | ENSP00000343930 | ENSP00000344782 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | growth factor independent 1B transcription repressor; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling path [...] | 0.482 |
| KLHL17 | GRIK2 | ENSP00000343930 | ENSP00000397026 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | glutamate receptor, ionotropic, kainate 2 | 0.903 |
| KLHL17 | HEATR8 | ENSP00000343930 | ENSP00000396622 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | HEAT repeat containing 8 | 0.471 |
| KLHL17 | LRRIQ3 | ENSP00000343930 | ENSP00000346414 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | leucine-rich repeats and IQ motif containing 3 | 0.472 |
| KLHL17 | PCNX | ENSP00000343930 | ENSP00000304192 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | pecanex homolog (Drosophila) | 0.489 |
| KLHL17 | PCNXL3 | ENSP00000343930 | ENSP00000347931 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | pecanex-like 3 (Drosophila) | 0.489 |
| LRRIQ3 | KLHL17 | ENSP00000346414 | ENSP00000343930 | leucine-rich repeats and IQ motif containing 3 | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.472 |
| PCNX | KLHL17 | ENSP00000304192 | ENSP00000343930 | pecanex homolog (Drosophila) | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.489 |
| PCNXL3 | KLHL17 | ENSP00000347931 | ENSP00000343930 | pecanex-like 3 (Drosophila) | kelch-like 17 (Drosophila); Substrate-recognition component of some cullin-RING- based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex. The BCR(KLHL17) mediates the ubiquitination and subsequenct degradation of GLUR6. May play a role in the actin-based neuronal function (By similarity) | 0.489 |
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