PPOX protein (Homo sapiens) - STRING network view

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PPOX

protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX (477 aa)

Predicted Functional Partners:

FECH

0.995

CPOX

0.988

UROD

0.900

UROS

0.827

ACE

0.744

ENSG00000264813

0.738

ACE2

0.738

ALAD

0.719

ST6GALNAC1

0.608

SLC6A1

0.583

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSP00000290866	ENSP00000252519	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	0.917
ACE	PPOX	ENSP00000290866	ENSP00000343943	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.744
ACE2	ACE	ENSP00000252519	ENSP00000290866	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety	0.917
ACE2	PPOX	ENSP00000252519	ENSP00000343943	angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.738
ALAD	CPOX	ENSP00000386284	ENSP00000264193	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	0.854
ALAD	FECH	ENSP00000386284	ENSP00000372326	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	0.906
ALAD	PPOX	ENSP00000386284	ENSP00000343943	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.719
ALAD	UROD	ENSP00000386284	ENSP00000246337	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.955
ALAD	UROS	ENSP00000386284	ENSP00000357775	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)	0.956
CPOX	ALAD	ENSP00000264193	ENSP00000386284	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	0.854
CPOX	FECH	ENSP00000264193	ENSP00000372326	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	0.899
CPOX	PPOX	ENSP00000264193	ENSP00000343943	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.988
CPOX	UROD	ENSP00000264193	ENSP00000246337	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.995
CPOX	UROS	ENSP00000264193	ENSP00000357775	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)	0.818
ENSG00000264813	PPOX	ENSP00000464149	ENSP00000343943	Angiotensin-converting enzyme; Uncharacterized protein	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.738
FECH	ALAD	ENSP00000372326	ENSP00000386284	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	aminolevulinate dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen	0.906
FECH	CPOX	ENSP00000372326	ENSP00000264193	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	coproporphyrinogen oxidase; Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III	0.899
FECH	PPOX	ENSP00000372326	ENSP00000343943	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	protoporphyrinogen oxidase; Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX	0.995
FECH	UROD	ENSP00000372326	ENSP00000246337	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III	0.950
FECH	UROS	ENSP00000372326	ENSP00000357775	ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX (By similarity)	uroporphyrinogen III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme)	0.844

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