node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ACSL4 | AUTS2 | ENSP00000339787 | ENSP00000344087 | acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates | autism susceptibility candidate 2 | 0.806 |
AUTS2 | ACSL4 | ENSP00000344087 | ENSP00000339787 | autism susceptibility candidate 2 | acyl-CoA synthetase long-chain family member 4; Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates | 0.806 |
AUTS2 | C15orf32 | ENSP00000344087 | ENSP00000330267 | autism susceptibility candidate 2 | chromosome 15 open reading frame 32 | 0.502 |
AUTS2 | CADPS2 | ENSP00000344087 | ENSP00000398481 | autism susceptibility candidate 2 | Ca++-dependent secretion activator 2 | 0.860 |
AUTS2 | CNTNAP2 | ENSP00000344087 | ENSP00000354778 | autism susceptibility candidate 2 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | 0.660 |
AUTS2 | CSNK2A1 | ENSP00000344087 | ENSP00000217244 | autism susceptibility candidate 2 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | 0.789 |
AUTS2 | DYRK1A | ENSP00000344087 | ENSP00000381932 | autism susceptibility candidate 2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | 0.745 |
AUTS2 | ELN | ENSP00000344087 | ENSP00000252034 | autism susceptibility candidate 2 | elastin | 0.535 |
AUTS2 | NRG3 | ENSP00000344087 | ENSP00000361214 | autism susceptibility candidate 2 | neuregulin 3; Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes | 0.758 |
AUTS2 | PTCHD1 | ENSP00000344087 | ENSP00000368666 | autism susceptibility candidate 2 | patched domain containing 1 | 0.561 |
AUTS2 | SHANK3 | ENSP00000344087 | ENSP00000442518 | autism susceptibility candidate 2 | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.497 |
C15orf32 | AUTS2 | ENSP00000330267 | ENSP00000344087 | chromosome 15 open reading frame 32 | autism susceptibility candidate 2 | 0.502 |
CADPS2 | AUTS2 | ENSP00000398481 | ENSP00000344087 | Ca++-dependent secretion activator 2 | autism susceptibility candidate 2 | 0.860 |
CADPS2 | DYRK1A | ENSP00000398481 | ENSP00000381932 | Ca++-dependent secretion activator 2 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | 0.757 |
CADPS2 | NRG3 | ENSP00000398481 | ENSP00000361214 | Ca++-dependent secretion activator 2 | neuregulin 3; Direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. Does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. May be a survival factor for oligodendrocytes | 0.846 |
CNTNAP2 | AUTS2 | ENSP00000354778 | ENSP00000344087 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | autism susceptibility candidate 2 | 0.660 |
CNTNAP2 | PTCHD1 | ENSP00000354778 | ENSP00000368666 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | patched domain containing 1 | 0.514 |
CNTNAP2 | SHANK3 | ENSP00000354778 | ENSP00000442518 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | SH3 and multiple ankyrin repeat domains 3; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors via complexes with GKAP/PSD-95 and Homer, respectively, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction | 0.635 |
CSNK2A1 | AUTS2 | ENSP00000217244 | ENSP00000344087 | casein kinase 2, alpha 1 polypeptide; Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Regulates numerous cellular processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a regulatory node which integrates and coordinates numerous signals leading to an appropriate cellular response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly che [...] | autism susceptibility candidate 2 | 0.789 |
DYRK1A | AUTS2 | ENSP00000381932 | ENSP00000344087 | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A; May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates such as CRY2, FOXO1 and SIRT1 | autism susceptibility candidate 2 | 0.745 |