node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APLNR | APP | ENSP00000257254 | ENSP00000284981 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | amyloid beta (A4) precursor protein | 0.904 |
APLNR | CHRM2 | ENSP00000257254 | ENSP00000319984 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | cholinergic receptor, muscarinic 2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition | 0.901 |
APLNR | CNR1 | ENSP00000257254 | ENSP00000358511 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | cannabinoid receptor 1 (brain) | 0.902 |
APLNR | DRD2 | ENSP00000257254 | ENSP00000354859 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | 0.900 |
APLNR | GRM8 | ENSP00000257254 | ENSP00000344173 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | glutamate receptor, metabotropic 8 | 0.955 |
APLNR | HRH3 | ENSP00000257254 | ENSP00000342560 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | histamine receptor H3; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization | 0.900 |
APLNR | HTR1A | ENSP00000257254 | ENSP00000316244 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.901 |
APLNR | NPY | ENSP00000257254 | ENSP00000242152 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.916 |
APLNR | NPY5R | ENSP00000257254 | ENSP00000339377 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | neuropeptide Y receptor Y5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders | 0.900 |
APLNR | OPRM1 | ENSP00000257254 | ENSP00000394624 | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | opioid receptor, mu 1 | 0.900 |
APP | APLNR | ENSP00000284981 | ENSP00000257254 | amyloid beta (A4) precursor protein | apelin receptor; Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity. Alternative coreceptor with CD4 for HIV-1 infection; may be involved in the development of AIDS dementia | 0.904 |
APP | CHRM2 | ENSP00000284981 | ENSP00000319984 | amyloid beta (A4) precursor protein | cholinergic receptor, muscarinic 2; The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition | 0.907 |
APP | CNR1 | ENSP00000284981 | ENSP00000358511 | amyloid beta (A4) precursor protein | cannabinoid receptor 1 (brain) | 0.911 |
APP | DRD2 | ENSP00000284981 | ENSP00000354859 | amyloid beta (A4) precursor protein | dopamine receptor D2; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase (By similarity) | 0.904 |
APP | GRM8 | ENSP00000284981 | ENSP00000344173 | amyloid beta (A4) precursor protein | glutamate receptor, metabotropic 8 | 0.964 |
APP | HRH3 | ENSP00000284981 | ENSP00000342560 | amyloid beta (A4) precursor protein | histamine receptor H3; The H3 subclass of histamine receptors could mediate the histamine signals in CNS and peripheral nervous system. Signals through the inhibition of adenylate cyclase and displays high constitutive activity (spontaneous activity in the absence of agonist). Agonist stimulation of isoform 3 neither modified adenylate cyclase activity nor induced intracellular calcium mobilization | 0.900 |
APP | HTR1A | ENSP00000284981 | ENSP00000316244 | amyloid beta (A4) precursor protein | 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled; This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity | 0.909 |
APP | NPY | ENSP00000284981 | ENSP00000242152 | amyloid beta (A4) precursor protein | neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone | 0.917 |
APP | NPY5R | ENSP00000284981 | ENSP00000339377 | amyloid beta (A4) precursor protein | neuropeptide Y receptor Y5; Receptor for neuropeptide Y and peptide YY. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Seems to be associated with food intake. Could be involved in feeding disorders | 0.900 |
APP | OPRM1 | ENSP00000284981 | ENSP00000394624 | amyloid beta (A4) precursor protein | opioid receptor, mu 1 | 0.912 |