| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| FOXP3 | IL17A | ENSP00000365380 | ENSP00000344192 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.962 |
| FOXP3 | IL17RA | ENSP00000365380 | ENSP00000320936 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.492 |
| FOXP3 | IL22 | ENSP00000365380 | ENSP00000329384 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.721 |
| FOXP3 | IL6 | ENSP00000365380 | ENSP00000258743 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.944 |
| FOXP3 | NFKB1 | ENSP00000365380 | ENSP00000226574 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.558 |
| FOXP3 | STAT1 | ENSP00000365380 | ENSP00000354394 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | signal transducer and activator of transcription 1, 91kDa | 0.963 |
| FOXP3 | STAT3 | ENSP00000365380 | ENSP00000264657 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.977 |
| FOXP3 | TGFB1 | ENSP00000365380 | ENSP00000221930 | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.984 |
| IL17A | FOXP3 | ENSP00000344192 | ENSP00000365380 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.962 |
| IL17A | IL17RA | ENSP00000344192 | ENSP00000320936 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | 0.999 |
| IL17A | IL17RC | ENSP00000344192 | ENSP00000295981 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 17 receptor C | 0.953 |
| IL17A | IL22 | ENSP00000344192 | ENSP00000329384 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 22; Cytokine that contributes to the inflammatory response in vivo | 0.973 |
| IL17A | IL6 | ENSP00000344192 | ENSP00000258743 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | interleukin 6 (interferon, beta 2); Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig- secreting cells Involved in lymphocyte and monocyte differentiation. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and [...] | 0.993 |
| IL17A | NFKB1 | ENSP00000344192 | ENSP00000226574 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to b [...] | 0.956 |
| IL17A | STAT1 | ENSP00000344192 | ENSP00000354394 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | signal transducer and activator of transcription 1, 91kDa | 0.956 |
| IL17A | STAT3 | ENSP00000344192 | ENSP00000264657 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | signal transducer and activator of transcription 3 (acute-phase response factor); Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity | 0.993 |
| IL17A | TGFB1 | ENSP00000344192 | ENSP00000221930 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | transforming growth factor, beta 1; Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts | 0.968 |
| IL17A | TRAF3IP2 | ENSP00000344192 | ENSP00000357750 | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | TRAF3 interacting protein 2 | 0.960 |
| IL17RA | FOXP3 | ENSP00000320936 | ENSP00000365380 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | forkhead box P3; Probable transcription factor. Plays a critical role in the control of immune response | 0.492 |
| IL17RA | IL17A | ENSP00000320936 | ENSP00000344192 | interleukin 17 receptor A; Receptor for IL17A, IL17F and, in dimer with IL17RE, for IL17C. Binds its IL17A ligand with low affinity, suggesting that additional components are involved in IL17A-induced signaling | interleukin 17A; Induces stromal cells to produce proinflammatory and hematopoietic cytokines. Enhances the surface expression of ICAM1/intracellular adhesion molecule 1 in fibroblasts | 0.999 |
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