node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ANGPT4 | RNASE1 | ENSP00000371347 | ENSP00000344193 | angiopoietin 4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis | ribonuclease, RNase A family, 1 (pancreatic) | 0.457 |
GLUD1 | GLUD2 | ENSP00000277865 | ENSP00000327589 | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | 0.802 |
GLUD1 | RNASE1 | ENSP00000277865 | ENSP00000344193 | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | ribonuclease, RNase A family, 1 (pancreatic) | 0.746 |
GLUD2 | GLUD1 | ENSP00000327589 | ENSP00000277865 | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | 0.802 |
GLUD2 | RNASE1 | ENSP00000327589 | ENSP00000344193 | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | ribonuclease, RNase A family, 1 (pancreatic) | 0.689 |
RNASE1 | ANGPT4 | ENSP00000344193 | ENSP00000371347 | ribonuclease, RNase A family, 1 (pancreatic) | angiopoietin 4; Binds to TEK/TIE2, modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2. Promotes endothelial cell survival, migration and angiogenesis | 0.457 |
RNASE1 | GLUD1 | ENSP00000344193 | ENSP00000277865 | ribonuclease, RNase A family, 1 (pancreatic) | glutamate dehydrogenase 1; May be involved in learning and memory reactions by increasing the turnover of the excitatory neurotransmitter glutamate (By similarity) | 0.746 |
RNASE1 | GLUD2 | ENSP00000344193 | ENSP00000327589 | ribonuclease, RNase A family, 1 (pancreatic) | glutamate dehydrogenase 2; Important for recycling the chief excitatory neurotransmitter, glutamate, during neurotransmission | 0.689 |
RNASE1 | RNASE11 | ENSP00000344193 | ENSP00000338288 | ribonuclease, RNase A family, 1 (pancreatic) | ribonuclease, RNase A family, 11 (non-active) | 0.501 |
RNASE1 | RNASEL | ENSP00000344193 | ENSP00000356530 | ribonuclease, RNase A family, 1 (pancreatic) | ribonuclease L (2’,5’-oligoisoadenylate synthetase-dependent); Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosi [...] | 0.659 |
RNASE1 | RNH1 | ENSP00000344193 | ENSP00000346402 | ribonuclease, RNase A family, 1 (pancreatic) | ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis | 0.982 |
RNASE1 | TMEM110 | ENSP00000344193 | ENSP00000347195 | ribonuclease, RNase A family, 1 (pancreatic) | transmembrane protein 110 | 0.407 |
RNASE11 | RNASE1 | ENSP00000338288 | ENSP00000344193 | ribonuclease, RNase A family, 11 (non-active) | ribonuclease, RNase A family, 1 (pancreatic) | 0.501 |
RNASEL | RNASE1 | ENSP00000356530 | ENSP00000344193 | ribonuclease L (2’,5’-oligoisoadenylate synthetase-dependent); Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress- response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosi [...] | ribonuclease, RNase A family, 1 (pancreatic) | 0.659 |
RNH1 | RNASE1 | ENSP00000346402 | ENSP00000344193 | ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis | ribonuclease, RNase A family, 1 (pancreatic) | 0.982 |
TMEM110 | RNASE1 | ENSP00000347195 | ENSP00000344193 | transmembrane protein 110 | ribonuclease, RNase A family, 1 (pancreatic) | 0.407 |