| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CAD | CPS1 | ENSP00000264705 | ENSP00000402608 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | 0.999 |
| CAD | GMPS | ENSP00000264705 | ENSP00000419851 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | 0.992 |
| CAD | SLC23A2 | ENSP00000264705 | ENSP00000344322 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.944 |
| CAD | UCKL1 | ENSP00000264705 | ENSP00000346155 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.894 |
| CAD | UMPS | ENSP00000264705 | ENSP00000232607 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | uridine monophosphate synthetase | 0.998 |
| CPS1 | CAD | ENSP00000402608 | ENSP00000264705 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.999 |
| CPS1 | GMPS | ENSP00000402608 | ENSP00000419851 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | 0.983 |
| CPS1 | SLC23A2 | ENSP00000402608 | ENSP00000344322 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.798 |
| CPS1 | UCKL1 | ENSP00000402608 | ENSP00000346155 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.804 |
| CPS1 | UMPS | ENSP00000402608 | ENSP00000232607 | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | uridine monophosphate synthetase | 0.995 |
| GMPS | CAD | ENSP00000419851 | ENSP00000264705 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.992 |
| GMPS | CPS1 | ENSP00000419851 | ENSP00000402608 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | carbamoyl-phosphate synthase 1, mitochondrial; Involved in the urea cycle of ureotelic animals where the enzyme plays an important role in removing excess ammonia from the cell | 0.983 |
| GMPS | SLC23A2 | ENSP00000419851 | ENSP00000344322 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.641 |
| GMPS | UCKL1 | ENSP00000419851 | ENSP00000346155 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation | 0.865 |
| GMPS | UMPS | ENSP00000419851 | ENSP00000232607 | guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division | uridine monophosphate synthetase | 0.913 |
| LCT | SLC23A2 | ENSP00000264162 | ENSP00000344322 | lactase; LPH splits lactose in the small intestine | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.687 |
| LCT | UMPS | ENSP00000264162 | ENSP00000232607 | lactase; LPH splits lactose in the small intestine | uridine monophosphate synthetase | 0.498 |
| MATR3 | SLC23A2 | ENSP00000354346 | ENSP00000344322 | matrin 3; May play a role in transcription or may interact with other nuclear matrix proteins to form the internal fibrogranular network. In association with the SFPQ-NONO heteromer may play a role in nuclear retention of defective RNAs | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.807 |
| NOS1 | SLC23A2 | ENSP00000337459 | ENSP00000344322 | nitric oxide synthase 1 (neuronal); Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In the brain and peripheral nervous system, NO displays many properties of a neurotransmitter. Probably has nitrosylase activity and mediates cysteine S-nitrosylation of cytoplasmic target proteins such SRR | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.780 |
| SFTPB | SLC23A2 | ENSP00000377409 | ENSP00000344322 | surfactant protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air- liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter | solute carrier family 23 (nucleobase transporters), member 2; Sodium/ascorbate cotransporter. Mediates electrogenic uptake of vitamin C, with a stoichiometry of 2 Na(+) for each ascorbate | 0.622 |
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