FCF1 protein (Homo sapiens) - STRING network view

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FCF1

FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity) (198 aa)

Predicted Functional Partners:

DNTTIP2

0.936

MPHOSPH10

0.897

FAF1

0.860

RCL1

0.782

IMP3

0.767

NOB1

0.751

RTCA

0.742

UTP6

0.737

NIP7

0.733

RPF1

0.729

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DNTTIP2	FAF1	ENSP00000411010	ENSP00000360843	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis	0.860
DNTTIP2	FCF1	ENSP00000411010	ENSP00000344393	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	0.936
DNTTIP2	IMP3	ENSP00000411010	ENSP00000326981	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.728
DNTTIP2	MPHOSPH10	ENSP00000411010	ENSP00000244230	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.527
DNTTIP2	NIP7	ENSP00000411010	ENSP00000254940	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.814
DNTTIP2	RCL1	ENSP00000411010	ENSP00000371169	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	RNA terminal phosphate cyclase-like 1; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity)	0.475
DNTTIP2	RPF1	ENSP00000411010	ENSP00000359688	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis	0.739
DNTTIP2	RTCA	ENSP00000411010	ENSP00000260563	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	RNA 3’-terminal phosphate cyclase; Catalyzes the conversion of 3’-phosphate to a 2’,3’- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps- (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA- N3’PP5’A; (C) and attack of the adjacent 2’-hydroxyl on the 3’- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing	0.475
DNTTIP2	UTP6	ENSP00000411010	ENSP00000261708	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	UTP6, small subunit (SSU) processome component, homolog (yeast); Involved in nucleolar processing of pre-18S ribosomal RNA (By similarity)	0.662
FAF1	DNTTIP2	ENSP00000360843	ENSP00000411010	Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	0.860
FAF1	FCF1	ENSP00000360843	ENSP00000344393	Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	0.860
FCF1	DNTTIP2	ENSP00000344393	ENSP00000411010	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	deoxynucleotidyltransferase, terminal, interacting protein 2; Regulates the transcriptional activity of DNTT and ESR1. May function as a chromatin remodeling protein	0.936
FCF1	FAF1	ENSP00000344393	ENSP00000360843	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	Fas (TNFRSF6) associated factor 1; Potentiates but cannot initiate FAS-induced apoptosis	0.860
FCF1	IMP3	ENSP00000344393	ENSP00000326981	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	IMP3, U3 small nucleolar ribonucleoprotein, homolog (yeast); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.767
FCF1	MPHOSPH10	ENSP00000344393	ENSP00000244230	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein); Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing	0.897
FCF1	NIP7	ENSP00000344393	ENSP00000254940	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	nuclear import 7 homolog (S. cerevisiae); Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly	0.733
FCF1	NOB1	ENSP00000344393	ENSP00000268802	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	NIN1/RPN12 binding protein 1 homolog (S. cerevisiae); May play a role in mRNA degradation	0.751
FCF1	RCL1	ENSP00000344393	ENSP00000371169	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	RNA terminal phosphate cyclase-like 1; Does not have cyclase activity. Plays a role in 40S- ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA (By similarity)	0.782
FCF1	RPF1	ENSP00000344393	ENSP00000359688	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	ribosome production factor 1 homolog (S. cerevisiae); May be required for ribosome biogenesis	0.729
FCF1	RTCA	ENSP00000344393	ENSP00000260563	FCF1 small subunit (SSU) processome component homolog (S. cerevisiae); Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly (By similarity)	RNA 3’-terminal phosphate cyclase; Catalyzes the conversion of 3’-phosphate to a 2’,3’- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps- (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3’P to produce RNA- N3’PP5’A; (C) and attack of the adjacent 2’-hydroxyl on the 3’- phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing	0.742

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