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SLC5A1 SLC5A1 ENSG00000255275 ENSG00000255275 O3FAR1 O3FAR1 TAS1R3 TAS1R3 TAS1R2 TAS1R2 IFFO2 IFFO2 TAS1R1 TAS1R1 ALDH4A1 ALDH4A1 GNAT3 GNAT3 TRPM5 TRPM5 GNAS GNAS
"TAS1R3" - taste receptor, type 1, member 3 in Homo sapiens
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Predicted Interactions
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TAS1R3taste receptor, type 1, member 3; Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate). TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose (By similarity). Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses (852 aa)    
Predicted Functional Partners:
GNAT3
guanine nucleotide binding protein, alpha transducing 3; Guanine nucleotide-binding protein (G protein) alpha subunit playing a prominent role in bitter and sweet taste transduction as well as in umami (monosodium glutamate, monopotassium glutamate, and inosine monophosphate) taste transduction. Transduction by this alpha subunit involves coupling of specific cell-surface receptors with a cGMP-phosphodiesterase; Activation of phosphodiesterase lowers intracellular levels of cAMP and cGMP which may open a cyclic nucleotide-suppressible cation channel leading to influx of calcium, ultima [...] (354 aa)
          score_image score_image   0.980
TAS1R2
taste receptor, type 1, member 2; Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (839 aa)
        score_image score_image score_image score_image 0.964
TAS1R1
taste receptor, type 1, member 1 (841 aa)
        score_image score_image score_image score_image 0.963
TRPM5
transient receptor potential cation channel, subfamily M, member 5; Voltage-modulated Ca(2+)-activated, monovalent cation channel (VCAM) that mediates a transient membrane depolarization and plays a central role in taste transduction. Monovalent- specific, non-selective cation channel that mediates the transport of Na(+), K(+) and Cs(+) ions equally well. Activated directly by increases in intracellular Ca(2+), but is impermeable to it. Gating is voltage-dependent and displays rapid activation and deactivation kinetics upon channel stimulation even during sustained elevations in Ca(2+) [...] (1165 aa)
            score_image   0.834
SLC5A1
solute carrier family 5 (sodium/glucose cotransporter), member 1; Actively transports glucose into cells by Na(+) cotransport with a Na(+) to glucose coupling ratio of 2-1. Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules (664 aa)
            score_image   0.821
ALDH4A1
aldehyde dehydrogenase 4 family, member A1 (563 aa)
            score_image   0.806
GNAS
GNAS complex locus; Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase- it activates the cyclase in response to beta-adrenergic stimuli. XLas isoforms interact with the same set of receptors as Gnas isoforms (By similarity) (1037 aa)
          score_image     0.800
ENSG00000255275
annotation not available (296 aa)
            score_image   0.794
IFFO2
intermediate filament family orphan 2 (517 aa)
            score_image   0.794
O3FAR1
omega-3 fatty acid receptor 1; Receptor for medium and long-chain free fatty acids (FFAs). Signals via a G(q)/G(11)-coupled pathway. Acts as a receptor for omega-3 fatty acids and mediates robust anti- inflammatory effects, particularly in macrophages and fat cells. The anti-inflammatory effects involve inhibition of TAK1 through a beta-arrestin 2 (ARRB2)/TAB1-dependent effect, but independent of the G(q)/G(11)-coupled pathway. Mediates potent insulin sensitizing and antidiabetic effects by repressing macrophage- induced tissue inflammation. May mediate the taste of fatty acids. Mediat [...] (377 aa)
            score_image   0.668
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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