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STRINGSTRING
AHCYL1 AHCYL1 AHCYL2 AHCYL2 UBC UBC MTR MTR BHMT BHMT CBS CBS CTH CTH AHCY AHCY SHMT1 SHMT1 SHMT2 SHMT2 SDS SDS
"CBS" - cystathionine-beta-synthase in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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fusion edge
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homology edge
protein homology
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CBScystathionine-beta-synthase; Only known pyridoxal phosphate-dependent enzyme that contains heme. Important regulator of hydrogen sulfide, especially in the brain, utilizing cysteine instead of serine to catalyze the formation of hydrogen sulfide. Hydrogen sulfide is a gastratransmitter with signaling and cytoprotective effects such as acting as a neuromodulator in the brain to protect neurons against hypoxic injury (By similarity) (551 aa)    
Predicted Functional Partners:
CTH
cystathionase (cystathionine gamma-lyase); Catalyzes the last step in the trans-sulfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molecules to lanthionine and hydrogen sulfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molecule hydrogen sulfide (H2S), and so contributes to the regulation of blood pressure. Acts as a cysteine-protein sulfhydrase by mediating sulfhydration [...] (405 aa)
score_image   score_image score_image   score_image score_image   0.997
BHMT
betaine--homocysteine S-methyltransferase; Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline (406 aa)
          score_image score_image   0.981
AHCY
adenosylhomocysteinase; Adenosylhomocysteine is a competitive inhibitor of S- adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine (432 aa)
      score_image   score_image score_image   0.976
MTR
5-methyltetrahydrofolate-homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate (By similarity) (1265 aa)
          score_image score_image   0.971
SHMT1
serine hydroxymethyltransferase 1 (soluble); Interconversion of serine and glycine (By similarity) (483 aa)
          score_image score_image   0.969
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial); Contributes to the de novo mitochondrial thymidylate biosynthesis pathway. Required to prevent uracil accumulation in mtDNA. Interconversion of serine and glycine. Associates with mitochondrial DNA (504 aa)
          score_image score_image   0.961
AHCYL2
adenosylhomocysteinase-like 2 (611 aa)
      score_image   score_image score_image   0.940
AHCYL1
adenosylhomocysteinase-like 1 (530 aa)
      score_image   score_image score_image   0.937
UBC
ubiquitin C (685 aa)
        score_image   score_image   0.937
SDS
serine dehydratase (328 aa)
          score_image score_image   0.926
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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