Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RNF133 | ring finger protein 133; Has E3 ubiquitin-protein ligase activity (By similarity) (376 aa) | ||||||||||||
Predicted Functional Partners:
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 | OR1C1 | olfactory receptor, family 1, subfamily C, member 1; Odorant receptor (Potential) (314 aa) |
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0.564 | ||||||||||
 | OR4M2 | olfactory receptor, family 4, subfamily M, member 2; Odorant receptor (Potential) (313 aa) |
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0.563 | ||||||||||
 | RNF113B | ring finger protein 113B (322 aa) |
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0.563 | ||||||||||
 | ODF3L2 | outer dense fiber of sperm tails 3-like 2 (289 aa) |
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0.560 | ||||||||||
 | OR4N4 | olfactory receptor, family 4, subfamily N, member 4; Odorant receptor (Potential) (316 aa) |
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0.538 | ||||||||||
 | RNF166 | ring finger protein 166 (237 aa) |
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0.536 | ||||||||||
 | UBE2U | ubiquitin-conjugating enzyme E2U (putative); Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity) (226 aa) |
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0.496 | ||||||||||
 | RNF181 | ring finger protein 181; E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates (153 aa) |
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0.482 | ||||||||||
 | MARCH11 | membrane-associated ring finger (C3HC4) 11; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids (By similarity) (402 aa) |
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0.472 | ||||||||||
 | RFWD3 | ring finger and WD repeat domain 3; E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA dam [...] (774 aa) |
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0.467 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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