| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AARSD1 | C21orf2 | ENSP00000402835 | ENSP00000344566 | alanyl-tRNA synthetase domain containing 1 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.485 |
| AIRE | C21orf2 | ENSP00000291582 | ENSP00000344566 | autoimmune regulator; Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5’-. ATTGGTTA-3’ combined with a 5’-TTATTA-3’ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ’Lys-4’, not phosphorylated at ’Thr-3’ and not methylated at ’Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a trans [...] | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.688 |
| AIRE | MAEA | ENSP00000291582 | ENSP00000302830 | autoimmune regulator; Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5’-. ATTGGTTA-3’ combined with a 5’-TTATTA-3’ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ’Lys-4’, not phosphorylated at ’Thr-3’ and not methylated at ’Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a trans [...] | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.507 |
| ATOX1 | C21orf2 | ENSP00000316854 | ENSP00000344566 | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.557 |
| C21orf2 | AARSD1 | ENSP00000344566 | ENSP00000402835 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | alanyl-tRNA synthetase domain containing 1 | 0.485 |
| C21orf2 | AIRE | ENSP00000344566 | ENSP00000291582 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | autoimmune regulator; Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5’-. ATTGGTTA-3’ combined with a 5’-TTATTA-3’ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ’Lys-4’, not phosphorylated at ’Thr-3’ and not methylated at ’Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a trans [...] | 0.688 |
| C21orf2 | ATOX1 | ENSP00000344566 | ENSP00000316854 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | ATX1 antioxidant protein 1 homolog (yeast); Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense | 0.557 |
| C21orf2 | ENSG00000108825 | ENSP00000344566 | ENSP00000386621 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | PTGES3L-AARSD1 readthrough; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (By similarity) | 0.485 |
| C21orf2 | FXN | ENSP00000344566 | ENSP00000366482 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | 0.565 |
| C21orf2 | MAEA | ENSP00000344566 | ENSP00000302830 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | 0.869 |
| C21orf2 | MX1 | ENSP00000344566 | ENSP00000381599 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) | 0.749 |
| C21orf2 | PFKL | ENSP00000344566 | ENSP00000269848 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP | 0.753 |
| C21orf2 | RMND5A | ENSP00000344566 | ENSP00000283632 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.778 |
| C21orf2 | RMND5B | ENSP00000344566 | ENSP00000320623 | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.778 |
| ENSG00000108825 | C21orf2 | ENSP00000386621 | ENSP00000344566 | PTGES3L-AARSD1 readthrough; Functions in trans to edit the amino acid moiety from incorrectly charged tRNA(Ala) (By similarity) | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.485 |
| FXN | C21orf2 | ENSP00000366482 | ENSP00000344566 | frataxin; Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown usin [...] | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.565 |
| MAEA | AIRE | ENSP00000302830 | ENSP00000291582 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | autoimmune regulator; Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment; the preferred motif is a tandem repeat of 5’-. ATTGGTTA-3’ combined with a 5’-TTATTA-3’ box. Binds to nucleosomes (By similarity). Binds to chromatin and interacts selectively with histone H3 that is not methylated at ’Lys-4’, not phosphorylated at ’Thr-3’ and not methylated at ’Arg-2’. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a trans [...] | 0.507 |
| MAEA | C21orf2 | ENSP00000302830 | ENSP00000344566 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | chromosome 21 open reading frame 2; May play roles in cilia formation and/or maintenance (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization | 0.869 |
| MAEA | RMND5A | ENSP00000302830 | ENSP00000283632 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | required for meiotic nuclear division 5 homolog A (S. cerevisiae) | 0.949 |
| MAEA | RMND5B | ENSP00000302830 | ENSP00000320623 | macrophage erythroblast attacher; Plays a role in erythroblast enucleation and in the development of the mature macrophages. Mediates the attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages; This MAEA- mediated contact inhibits erythroid cells apoptosis. Participates to erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages. May contribute to nuclear architecture and cells division events | required for meiotic nuclear division 5 homolog B (S. cerevisiae) | 0.889 |
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