BTG3 protein (Homo sapiens) - STRING network view

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BTG3

BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase (296 aa)

Predicted Functional Partners:

CHEK1

0.919

CNOT7

0.664

ACACB

0.660

BANP

0.618

ACACA

0.609

AKNA

0.601

E2F1

0.576

NIPAL4

0.491

UBC

0.483

NPY

0.439

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACACA	ACACB	ENSP00000344789	ENSP00000341044	acetyl-CoA carboxylase alpha	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.999
ACACA	BTG3	ENSP00000344789	ENSP00000344609	acetyl-CoA carboxylase alpha	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	0.609
ACACA	E2F1	ENSP00000344789	ENSP00000345571	acetyl-CoA carboxylase alpha	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis	0.780
ACACA	UBC	ENSP00000344789	ENSP00000344818	acetyl-CoA carboxylase alpha	ubiquitin C	0.922
ACACB	ACACA	ENSP00000341044	ENSP00000344789	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	acetyl-CoA carboxylase alpha	0.999
ACACB	BTG3	ENSP00000341044	ENSP00000344609	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	0.660
ACACB	E2F1	ENSP00000341044	ENSP00000345571	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis	0.780
ACACB	NPY	ENSP00000341044	ENSP00000242152	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	neuropeptide Y; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone	0.400
ACACB	UBC	ENSP00000341044	ENSP00000344818	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	ubiquitin C	0.851
AKNA	BTG3	ENSP00000303769	ENSP00000344609	AT-hook transcription factor	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	0.601
AKNA	UBC	ENSP00000303769	ENSP00000344818	AT-hook transcription factor	ubiquitin C	0.483
BANP	BTG3	ENSP00000286122	ENSP00000344609	BTG3 associated nuclear protein; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity)	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	0.618
BTG3	ACACA	ENSP00000344609	ENSP00000344789	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	acetyl-CoA carboxylase alpha	0.609
BTG3	ACACB	ENSP00000344609	ENSP00000341044	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase	0.660
BTG3	AKNA	ENSP00000344609	ENSP00000303769	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	AT-hook transcription factor	0.601
BTG3	BANP	ENSP00000344609	ENSP00000286122	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	BTG3 associated nuclear protein; Controls V(D)J recombination during T-cell development by repressing T-cell receptor (TCR) beta enhancer function. Binds to scaffold/matrix attachment region beta (S/MARbeta), an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Represses cyclin D1 transcription by recruiting HDAC1 to its promoter, thereby diminishing H3K9ac, H3S10ph and H4K8ac levels. Promotes TP53 ’Ser-15’ phosphorylation and nuclear accumulation, which causes cell cycle arrest (By similarity)	0.618
BTG3	CHEK1	ENSP00000344609	ENSP00000388648	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	checkpoint kinase 1; Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at ’Ser-178’ and ’Thr-507’ and phosphorylation of C [...]	0.919
BTG3	CNOT7	ENSP00000344609	ENSP00000355279	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	CCR4-NOT transcription complex, subunit 7; Has 3’-5’ poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT8. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translation [...]	0.664
BTG3	E2F1	ENSP00000344609	ENSP00000345571	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	E2F transcription factor 1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5’-TTTC[CG]CGC- 3’ found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis	0.576
BTG3	NIPAL4	ENSP00000344609	ENSP00000311687	BTG family, member 3; Overexpression impairs serum-induced cell cycle progression from the G0/G1 to S phase	NIPA-like domain containing 4; Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Ba(2+), Mn(2+), Sr(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity). May be a receptor for ligands (trioxilins A3 and B3) from the hepoxilin pathway	0.491

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