Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | CCDC41 | coiled-coil domain containing 41 (701 aa) | ||||||||||||
Predicted Functional Partners:
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 | SCLT1 | sodium channel and clathrin linker 1; Adapter protein that links SCN10A to clathrin. Regulates SCN10A channel activity, possibly by promoting channel internalization (By similarity) (688 aa) |
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0.968 | |||||||||
 | CEP164 | centrosomal protein 164kDa; Plays a role in microtubule organization and/or maintenance for the formation of primary cilia (PC), a microtubule-based structure that protrudes from the surface of epithelial cells. Plays a critical role in G2/M checkpoint and nuclear divisions. A key player in the DNA damage-activated ATR/ATM signaling cascade since it is required for the proper phosphorylation of H2AX, RPA, CHEK2 and CHEK1. Plays a critical role in chromosome segregation, acting as a mediator required for the maintenance of genomic stability through modulation of MDC1, RPA and CHEK1 (1460 aa) |
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0.964 | |||||||||
 | CEP89 | centrosomal protein 89kDa (783 aa) |
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0.962 | |||||||||
 | FBF1 | Fas (TNFRSF6) binding factor 1; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3 (1133 aa) |
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0.956 | |||||||||
 | OR52N4 | olfactory receptor, family 52, subfamily N, member 4; Odorant receptor (Potential) (321 aa) |
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0.725 | ||||||||||
 | ANKRD20A2 | ankyrin repeat domain 20 family, member A2 (823 aa) |
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0.724 | ||||||||||
 | ANKRD20A3 | ankyrin repeat domain 20 family, member A3 (823 aa) |
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0.721 | ||||||||||
 | MYADML2 | myeloid-associated differentiation marker-like 2 (307 aa) |
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0.584 | ||||||||||
 | LRRCC1 | leucine rich repeat and coiled-coil centrosomal protein 1; Required for the organization of the mitotic spindle. Maintains the structural integrity of centrosomes during mitosis (1032 aa) |
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0.535 | ||||||||||
 | CCT6B | chaperonin containing TCP1, subunit 6B (zeta 2); Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity) (530 aa) |
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0.504 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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