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STRINGSTRING
SDPR SDPR RDH10 RDH10 DHRS1 DHRS1 MDM2 MDM2 DHRS2 DHRS2 ACACA ACACA UBC UBC TMEM209 TMEM209 ACACB ACACB DHRS3 DHRS3 MYB MYB
"DHRS2" - dehydrogenase/reductase (SDR family) member 2 in Homo sapiens
Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
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white nodes:
second shell of interactors
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
DHRS2dehydrogenase/reductase (SDR family) member 2; Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. May inhibit cell replication (300 aa)    
Predicted Functional Partners:
MYB
v-myb myeloblastosis viral oncogene homolog (avian) (761 aa)
            score_image   0.863
UBC
ubiquitin C (685 aa)
        score_image       0.646
DHRS1
dehydrogenase/reductase (SDR family) member 1 (313 aa)
    score_image score_image     score_image   0.625
DHRS3
dehydrogenase/reductase (SDR family) member 3; Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH (302 aa)
    score_image       score_image   0.608
RDH10
retinol dehydrogenase 10 (all-trans); Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinol to all-trans-retinal. Has no detectable activity towards 11-cis-retinol, 9-cis-retinol and 13-cis-retinol (341 aa)
    score_image       score_image   0.582
ACACA
acetyl-CoA carboxylase alpha (2383 aa)
score_image           score_image   0.581
ACACB
acetyl-CoA carboxylase beta; ACC-beta may be involved in the provision of malonyl-CoA or in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. Carries out three functions- biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase (2458 aa)
score_image           score_image   0.581
MDM2
Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) (497 aa)
        score_image   score_image   0.577
SDPR
serum deprivation response; May play a role in targeting PRKCA to caveolae (By similarity) (425 aa)
            score_image   0.566
TMEM209
transmembrane protein 209 (561 aa)
            score_image   0.528
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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