node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAB39L | ECM2 | ENSP00000261669 | ENSP00000344758 | calcium binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity) | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | 0.588 |
CAB39L | OGN | ENSP00000261669 | ENSP00000262551 | calcium binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity) | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.588 |
CNBD2 | ECM2 | ENSP00000340954 | ENSP00000344758 | cyclic nucleotide binding domain containing 2 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | 0.760 |
CNBD2 | OGN | ENSP00000340954 | ENSP00000262551 | cyclic nucleotide binding domain containing 2 | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.760 |
ECM2 | CAB39L | ENSP00000344758 | ENSP00000261669 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | calcium binding protein 39-like; Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1 (By similarity) | 0.588 |
ECM2 | CNBD2 | ENSP00000344758 | ENSP00000340954 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | cyclic nucleotide binding domain containing 2 | 0.760 |
ECM2 | HSP90AA1 | ENSP00000344758 | ENSP00000335153 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
ECM2 | HSP90AB1 | ENSP00000344758 | ENSP00000325875 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.799 |
ECM2 | HSP90B1 | ENSP00000344758 | ENSP00000299767 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.684 |
ECM2 | OGN | ENSP00000344758 | ENSP00000262551 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.857 |
ECM2 | PRKAR1A | ENSP00000344758 | ENSP00000351410 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.760 |
ECM2 | PRKAR1B | ENSP00000344758 | ENSP00000353415 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | protein kinase, cAMP-dependent, regulatory, type I, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.760 |
ECM2 | PRKAR2A | ENSP00000344758 | ENSP00000265563 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.760 |
ECM2 | PRKAR2B | ENSP00000344758 | ENSP00000265717 | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.760 |
HSP90AA1 | ECM2 | ENSP00000335153 | ENSP00000344758 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | extracellular matrix protein 2, female organ and adipocyte specific; Promotes matrix assembly and cell adhesiveness (By similarity) | 0.799 |
HSP90AA1 | HSP90AB1 | ENSP00000335153 | ENSP00000325875 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa alpha (cytosolic), class B member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | 0.999 |
HSP90AA1 | HSP90B1 | ENSP00000335153 | ENSP00000299767 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | heat shock protein 90kDa beta (Grp94), member 1; Molecular chaperone that functions in the processing and transport of secreted proteins. When associated with CNPY3, required for proper folding of Toll-like receptors (By similarity). Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity | 0.655 |
HSP90AA1 | OGN | ENSP00000335153 | ENSP00000262551 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | osteoglycin; Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2 | 0.804 |
HSP90AA1 | PRKAR1A | ENSP00000335153 | ENSP00000351410 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | protein kinase, cAMP-dependent, regulatory, type I, alpha; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells | 0.727 |
HSP90AA1 | PRKAR2B | ENSP00000335153 | ENSP00000265717 | heat shock protein 90kDa alpha (cytosolic), class A member 1; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function | protein kinase, cAMP-dependent, regulatory, type II, beta; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase | 0.916 |