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STRINGSTRING
RCOR3 RCOR3 HMG20B HMG20B KDM1A KDM1A GATA3 GATA3 RCOR2 RCOR2 RCOR1 RCOR1 HDAC2 HDAC2 GFI1B GFI1B EHMT2 EHMT2 MEGF8 MEGF8 GATA1 GATA1
"GFI1B" - growth factor independent 1B transcription repressor in Homo sapiens
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Predicted Interactions
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GFI1Bgrowth factor independent 1B transcription repressor; Essential proto-oncogenic transcriptional regulator necessary for development and differentiation of erythroid and megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation. Transcriptional repressor or activator depending on both promoter and cell type context; represses promoter activity of SOCS1 and SOCS3 and thus, may regulate cytokine signaling path [...] (330 aa)    
Predicted Functional Partners:
RCOR1
REST corepressor 1; Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase a [...] (482 aa)
        score_image   score_image   0.967
GATA1
GATA binding protein 1 (globin transcription factor 1); Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells (413 aa)
      score_image score_image   score_image   0.966
HMG20B
high mobility group 20B; Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters (317 aa)
        score_image   score_image   0.893
GATA3
GATA binding protein 3; Transcriptional activator which binds to the enhancer of the T-cell receptor alpha and delta genes. Binds to the consensus sequence 5’-AGATAG-3’ (444 aa)
        score_image   score_image   0.884
KDM1A
lysine (K)-specific demethylase 1A (876 aa)
        score_image   score_image   0.851
HDAC2
histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Forms transcriptional repressor complexes by associating with MAD, SIN3, YY1 and N-COR. Interacts in the late S-phase of DNA-replication with DNMT1 in the other transcriptional repressor complex composed o [...] (488 aa)
        score_image   score_image   0.849
RCOR2
REST corepressor 2; May act as a component of a corepressor complex that represses transcription (Potential) (523 aa)
        score_image   score_image   0.833
MEGF8
multiple EGF-like-domains 8 (2778 aa)
        score_image   score_image   0.793
RCOR3
REST corepressor 3; May act as a component of a corepressor complex that represses transcription (Potential) (553 aa)
        score_image   score_image   0.777
EHMT2
euchromatic histone-lysine N-methyltransferase 2 (1210 aa)
      score_image score_image   score_image   0.727
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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