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GMPR GMPR GMPR2 GMPR2 ADSS ADSS NT5E NT5E ATIC ATIC ADSSL1 ADSSL1 IMPDH1 IMPDH1 GMPS GMPS HPRT1 HPRT1 ITPA ITPA TPMT TPMT
"IMPDH1" - IMP (inosine 5'-monophosphate) dehydrogenase 1 in Homo sapiens
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Predicted Interactions
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protein homology
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Score
IMPDH1IMP (inosine 5’-monophosphate) dehydrogenase 1; Catalyzes the conversion of inosine 5’-phosphate (IMP) to xanthosine 5’-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors (By similarity) (599 aa)    
Predicted Functional Partners:
GMPS
guanine monphosphate synthetase; Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division (693 aa)
score_image   score_image score_image   score_image score_image   0.999
ATIC
5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase; Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis (592 aa)
score_image     score_image score_image score_image score_image   0.952
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa)
score_image       score_image score_image score_image   0.949
ADSS
adenylosuccinate synthase; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP (By similarity) (456 aa)
score_image     score_image   score_image score_image   0.945
HPRT1
hypoxanthine phosphoribosyltransferase 1; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5- phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (218 aa)
          score_image score_image   0.940
GMPR
guanosine monophosphate reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (345 aa)
score_image   score_image   score_image score_image score_image score_image 0.937
GMPR2
guanosine monophosphate reductase 2; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. Plays a role in modulating cellular differentiation (366 aa)
score_image   score_image   score_image score_image score_image score_image 0.933
TPMT
thiopurine S-methyltransferase (245 aa)
          score_image score_image   0.932
NT5E
5’-nucleotidase, ecto (CD73); Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities (574 aa)
          score_image score_image   0.926
ADSSL1
adenylosuccinate synthase like 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity) (500 aa)
score_image     score_image   score_image score_image   0.922
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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