node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASR | NKX2-4 | ENSP00000420194 | ENSP00000345147 | calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system | NK2 homeobox 4; Probable transcription factor | 0.650 |
CEBPG | NKX2-4 | ENSP00000284000 | ENSP00000345147 | CCAAT/enhancer binding protein (C/EBP), gamma; Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites | NK2 homeobox 4; Probable transcription factor | 0.667 |
DCUN1D1 | NKX2-4 | ENSP00000292782 | ENSP00000345147 | DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity) | NK2 homeobox 4; Probable transcription factor | 0.865 |
FGF2 | NKX2-4 | ENSP00000264498 | ENSP00000345147 | fibroblast growth factor 2 (basic) | NK2 homeobox 4; Probable transcription factor | 0.629 |
FGF2 | PTGS2 | ENSP00000264498 | ENSP00000356438 | fibroblast growth factor 2 (basic) | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.876 |
FGF8 | NKX2-4 | ENSP00000321797 | ENSP00000345147 | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | NK2 homeobox 4; Probable transcription factor | 0.602 |
NKX2-4 | CASR | ENSP00000345147 | ENSP00000420194 | NK2 homeobox 4; Probable transcription factor | calcium-sensing receptor; Senses changes in the extracellular concentration of calcium ions. The activity of this receptor is mediated by a G- protein that activates a phosphatidylinositol-calcium second messenger system | 0.650 |
NKX2-4 | CEBPG | ENSP00000345147 | ENSP00000284000 | NK2 homeobox 4; Probable transcription factor | CCAAT/enhancer binding protein (C/EBP), gamma; Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites | 0.667 |
NKX2-4 | DCUN1D1 | ENSP00000345147 | ENSP00000292782 | NK2 homeobox 4; Probable transcription factor | DCN1, defective in cullin neddylation 1, domain containing 1 (S. cerevisiae); Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes by enhancing the rate of cullins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the cullin component. Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression (By similarity) | 0.865 |
NKX2-4 | FGF2 | ENSP00000345147 | ENSP00000264498 | NK2 homeobox 4; Probable transcription factor | fibroblast growth factor 2 (basic) | 0.629 |
NKX2-4 | FGF8 | ENSP00000345147 | ENSP00000321797 | NK2 homeobox 4; Probable transcription factor | fibroblast growth factor 8 (androgen-induced); Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system | 0.602 |
NKX2-4 | PBX1 | ENSP00000345147 | ENSP00000405890 | NK2 homeobox 4; Probable transcription factor | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | 0.604 |
NKX2-4 | PTGS1 | ENSP00000345147 | ENSP00000354612 | NK2 homeobox 4; Probable transcription factor | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | 0.601 |
NKX2-4 | PTGS2 | ENSP00000345147 | ENSP00000356438 | NK2 homeobox 4; Probable transcription factor | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.601 |
NKX2-4 | SLC26A4 | ENSP00000345147 | ENSP00000265715 | NK2 homeobox 4; Probable transcription factor | solute carrier family 26, member 4; Sodium-independent transporter of chloride and iodide | 0.621 |
NKX2-4 | TOR1A | ENSP00000345147 | ENSP00000345719 | NK2 homeobox 4; Probable transcription factor | torsin family 1, member A (torsin A); May serve as a molecular chaperone assisting in the proper folding of secreted and/or membrane proteins. In the nucleus, displaces the nuclear membrane proteins SUN2, SYNE2 and SYNE3, leaving nuclear pores and SUN1 unchanged | 0.599 |
PBX1 | NKX2-4 | ENSP00000405890 | ENSP00000345147 | pre-B-cell leukemia homeobox 1; Binds the sequence 5’-ATCAATCAA-3’. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Isoform PBX1b as part of a PDX1-PBX1b-MEIS2b complex in pancreatic acinar cells is involved in the transcriptional activation of the ELA1 enhancer; the complex binds to the enhancer B element and cooperates with the transcription factor 1 complex (PTF1) bound to the enhancer A element [...] | NK2 homeobox 4; Probable transcription factor | 0.604 |
PTGS1 | NKX2-4 | ENSP00000354612 | ENSP00000345147 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | NK2 homeobox 4; Probable transcription factor | 0.601 |
PTGS1 | PTGS2 | ENSP00000354612 | ENSP00000356438 | prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase); May play an important role in regulating or promoting cell proliferation in some normal and neoplastically transformed cells | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | 0.592 |
PTGS2 | FGF2 | ENSP00000356438 | ENSP00000264498 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase); Mediates the formation of prostaglandins from arachidonate. May have a role as a major mediator of inflammation and/or a role for prostanoid signaling in activity-dependent plasticity | fibroblast growth factor 2 (basic) | 0.876 |