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LPHN2 LPHN2 SLC9A3 SLC9A3 DNM2 DNM2 SHARPIN SHARPIN SHANK2 SHANK2 LRTOMT LRTOMT CTTN CTTN DLG4 DLG4 DLGAP3 DLGAP3 DLGAP2 DLGAP2 DLGAP1 DLGAP1
"SHANK2" - SH3 and multiple ankyrin repeat domains 2 in Homo sapiens
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protein of unknown 3D structure
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second shell of interactors
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Predicted Interactions
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SHANK2SH3 and multiple ankyrin repeat domains 2; Seems to be an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction (1850 aa)    
Predicted Functional Partners:
CTTN
cortactin; Contributes to the organization of the actin cytoskeleton and cell structure. In complex with ABL1 and MYLK regulates cortical actin-based cytoskeletal rearrangement critical to sphingosine 1-phosphate (S1P)-mediated endothelial cell (EC) barrier enhancement. Plays a role in the regulation of cell migration. Plays a role in the invasiveness of cancer cells, and the formation of metastases (634 aa)
        score_image   score_image   0.970
DNM2
dynamin 2; Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Most probably involved in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (870 aa)
        score_image   score_image   0.939
DLG4
discs, large homolog 4 (Drosophila); Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B (By similarity) (767 aa)
      score_image score_image   score_image   0.932
SLC9A3
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3; Involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions. Major proton extruding system driven by the inward sodium ion chemical gradient. Plays an important role in signal transduction (834 aa)
            score_image   0.920
DLGAP1
discs, large (Drosophila) homolog-associated protein 1 (977 aa)
        score_image   score_image   0.896
LPHN2
latrophilin 2 (1403 aa)
            score_image   0.824
LRTOMT
leucine rich transmembrane and 0-methyltransferase domain containing; Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones (By similarity). Required for auditory function (291 aa)
            score_image   0.820
DLGAP2
discs, large (Drosophila) homolog-associated protein 2; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (975 aa)
        score_image   score_image   0.773
DLGAP3
discs, large (Drosophila) homolog-associated protein 3; May play a role in the molecular organization of synapses and neuronal cell signaling. Could be an adapter protein linking ion channel to the subsynaptic cytoskeleton. May induce enrichment of PSD-95/SAP90 at the plasma membrane (979 aa)
        score_image   score_image   0.752
SHARPIN
SHANK-associated RH domain interactor (387 aa)
        score_image   score_image   0.746
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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