node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASK | CNTNAP2 | ENSP00000367408 | ENSP00000354778 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | 0.624 |
CASK | EPB41 | ENSP00000367408 | ENSP00000345259 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.962 |
CASK | SDC2 | ENSP00000367408 | ENSP00000307046 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | syndecan 2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity) | 0.998 |
CASK | TJP1 | ENSP00000367408 | ENSP00000281537 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.607 |
CASK | TJP2 | ENSP00000367408 | ENSP00000438262 | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | tight junction protein 2 | 0.461 |
CNTNAP2 | CASK | ENSP00000354778 | ENSP00000367408 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.624 |
CNTNAP2 | EPB41 | ENSP00000354778 | ENSP00000345259 | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.913 |
EPB41 | CASK | ENSP00000345259 | ENSP00000367408 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.962 |
EPB41 | CNTNAP2 | ENSP00000345259 | ENSP00000354778 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction | 0.913 |
EPB41 | GYPC | ENSP00000345259 | ENSP00000259254 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | glycophorin C (Gerbich blood group); This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells | 0.988 |
EPB41 | NUMA1 | ENSP00000345259 | ENSP00000377298 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions | 0.940 |
EPB41 | OCLN | ENSP00000345259 | ENSP00000347379 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | occludin | 0.835 |
EPB41 | SDC2 | ENSP00000345259 | ENSP00000307046 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | syndecan 2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity) | 0.908 |
EPB41 | SLC4A1 | ENSP00000345259 | ENSP00000262418 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.859 |
EPB41 | SPTB | ENSP00000345259 | ENSP00000374372 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane | 0.858 |
EPB41 | TJP1 | ENSP00000345259 | ENSP00000281537 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells | 0.858 |
EPB41 | TJP2 | ENSP00000345259 | ENSP00000438262 | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | tight junction protein 2 | 0.992 |
GYPC | EPB41 | ENSP00000259254 | ENSP00000345259 | glycophorin C (Gerbich blood group); This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.988 |
GYPC | SLC4A1 | ENSP00000259254 | ENSP00000262418 | glycophorin C (Gerbich blood group); This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells | solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin | 0.404 |
NUMA1 | EPB41 | ENSP00000377298 | ENSP00000345259 | nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions | erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) | 0.940 |