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NUMA1 NUMA1 CNTNAP2 CNTNAP2 SPTB SPTB SDC2 SDC2 SLC4A1 SLC4A1 CASK CASK EPB41 EPB41 GYPC GYPC TJP1 TJP1 TJP2 TJP2 OCLN OCLN
"EPB41" - erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
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some 3D structure is known or predicted
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query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
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Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
EPB41erythrocyte membrane protein band 4.1 (elliptocytosis 1, RH-linked) (864 aa)    
Predicted Functional Partners:
TJP2
tight junction protein 2 (1221 aa)
        score_image score_image score_image   0.992
GYPC
glycophorin C (Gerbich blood group); This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells (128 aa)
        score_image   score_image   0.988
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family) (921 aa)
        score_image score_image score_image   0.962
NUMA1
nuclear mitotic apparatus protein 1; Highly abundant component of the nuclear matrix where it may serve a non-mitotic structural role, occupies the majority if the nuclear volume. Required for maintenance and establishment of the mitotic spindle poles, functionning as a tether linking bulk microtubules of the spindle to centrosomes. May be involved in coordination of the alignment of the mitotic spindle to the cellular polarity axis, which is a prerequisite for asymmetric cell divisions (2115 aa)
        score_image   score_image   0.940
CNTNAP2
contactin associated protein-like 2; May play a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Seems to demarcate the juxtaparanodal region of the axo-glial junction (1331 aa)
            score_image   0.913
SDC2
syndecan 2; Cell surface proteoglycan that bears heparan sulfate. Regulates dendritic arbor morphogenesis (By similarity) (201 aa)
          score_image score_image   0.908
SLC4A1
solute carrier family 4, anion exchanger, member 1 (erythrocyte membrane protein band 3, Diego blood group); Band 3 is the major integral glycoprotein of the erythrocyte membrane. Band 3 has two functional domains. Its integral domain mediates a 1-1 exchange of inorganic anions across the membrane, whereas its cytoplasmic domain provides binding sites for cytoskeletal proteins, glycolytic enzymes, and hemoglobin (911 aa)
        score_image   score_image   0.859
SPTB
spectrin, beta, erythrocytic; Spectrin is the major constituent of the cytoskeletal network underlying the erythrocyte plasma membrane. It associates with band 4.1 and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane (2328 aa)
        score_image   score_image   0.858
TJP1
tight junction protein 1; The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells (1748 aa)
            score_image   0.858
OCLN
occludin (522 aa)
            score_image   0.835
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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