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STRINGSTRING
C22orf25 C22orf25 NUS1 NUS1 C12orf23 C12orf23 C2orf18 C2orf18 CDS2 CDS2 CDS1 CDS1 VAMP7 VAMP7 UBC UBC SLC25A5 SLC25A5 CAD CAD SLC35A2 SLC35A2
"C2orf18" - chromosome 2 open reading frame 18 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored protein node
colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
neighborhood edge
gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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[Homology]
Score
C2orf18chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter (371 aa)    
Predicted Functional Partners:
C12orf23
chromosome 12 open reading frame 23 (116 aa)
            score_image   0.796
CDS2
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 (445 aa)
        score_image       0.726
CDS1
CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells (461 aa)
        score_image       0.726
NUS1
nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol (293 aa)
            score_image   0.707
SLC25A5
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation (298 aa)
        score_image   score_image   0.694
UBC
ubiquitin C (685 aa)
        score_image       0.637
C22orf25
chromosome 22 open reading frame 25 (276 aa)
            score_image   0.629
VAMP7
vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] (260 aa)
      score_image     score_image   0.534
CAD
carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) (2225 aa)
score_image       score_image       0.495
SLC35A2
solute carrier family 35 (UDP-galactose transporter), member A2; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function (396 aa)
            score_image   0.480
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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