node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C12orf23 | C2orf18 | ENSP00000280756 | ENSP00000345528 | chromosome 12 open reading frame 23 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | 0.796 |
C12orf23 | VAMP7 | ENSP00000280756 | ENSP00000262640 | chromosome 12 open reading frame 23 | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.479 |
C22orf25 | C2orf18 | ENSP00000332721 | ENSP00000345528 | chromosome 22 open reading frame 25 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | 0.629 |
C22orf25 | NUS1 | ENSP00000332721 | ENSP00000357480 | chromosome 22 open reading frame 25 | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol | 0.646 |
C2orf18 | C12orf23 | ENSP00000345528 | ENSP00000280756 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | chromosome 12 open reading frame 23 | 0.796 |
C2orf18 | C22orf25 | ENSP00000345528 | ENSP00000332721 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | chromosome 22 open reading frame 25 | 0.629 |
C2orf18 | CAD | ENSP00000345528 | ENSP00000264705 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | 0.495 |
C2orf18 | CDS1 | ENSP00000345528 | ENSP00000295887 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells | 0.726 |
C2orf18 | CDS2 | ENSP00000345528 | ENSP00000419879 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 0.726 |
C2orf18 | NUS1 | ENSP00000345528 | ENSP00000357480 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | nuclear undecaprenyl pyrophosphate synthase 1 homolog (S. cerevisiae); Acts as a specific receptor for the N-terminus of Nogo- B, a neural and cardiovascular regulator. Regulates the stability of nascent NPC2, thereby promoting trafficking of LDL-derived cholesterol | 0.707 |
C2orf18 | SLC25A5 | ENSP00000345528 | ENSP00000360671 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5; Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation | 0.694 |
C2orf18 | SLC35A2 | ENSP00000345528 | ENSP00000247138 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | solute carrier family 35 (UDP-galactose transporter), member A2; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function | 0.480 |
C2orf18 | UBC | ENSP00000345528 | ENSP00000344818 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | ubiquitin C | 0.637 |
C2orf18 | VAMP7 | ENSP00000345528 | ENSP00000262640 | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | vesicle-associated membrane protein 7; Involved in the targeting and/or fusion of transport vesicles to their target membrane during transport of proteins from the early endosome to the lysosome. Required for heterotypic fusion of late endosomes with lysosomes and homotypic lysosomal fusion. Required for calcium regulated lysosomal exocytosis. Involved in the export of chylomicrons from the endoplasmic reticulum to the cis Golgi. Required for exocytosis of mediators during eosinophil and neutrophil degranulation, and target cell killing by natural killer cells. Required for focal exocy [...] | 0.534 |
CAD | C2orf18 | ENSP00000264705 | ENSP00000345528 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | 0.495 |
CAD | CDS1 | ENSP00000264705 | ENSP00000295887 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells | 0.487 |
CAD | CDS2 | ENSP00000264705 | ENSP00000419879 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | 0.492 |
CAD | SLC35A2 | ENSP00000264705 | ENSP00000247138 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | solute carrier family 35 (UDP-galactose transporter), member A2; Transports nucleotide sugars from the cytosol into Golgi vesicles where glycosyltransferases function | 0.495 |
CAD | UBC | ENSP00000264705 | ENSP00000344818 | carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase; This protein is a "fusion" protein encoding four enzymatic activities of the pyrimidine pathway (GATase, CPSase, ATCase and DHOase) | ubiquitin C | 0.874 |
CDS1 | C2orf18 | ENSP00000295887 | ENSP00000345528 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 1; Provides CDP-diacylglycerol an important precursor for the synthesis of phosphatidylinositol (PtdIns), phosphatidylglycerol, and cardiolipin. Overexpression may amplify cellular signaling responses from cytokines. May also play an important role in the signal transduction mechanism of retina and neural cells | chromosome 2 open reading frame 18; Involved in the maintenance of mitochondrial membrane potential in pancreatic ductal adenocarcinoma (PDAC) cells. Promotes pancreatic ductal adenocarcinoma (PDAC) cell growth. May play a role as a nucleotide-sugar transporter | 0.726 |