ENO4 protein (Homo sapiens) - STRING network view

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Score

ENO4

enolase family member 4 (628 aa)

Predicted Functional Partners:

PGK1

0.985

PGK2

0.983

TPI1

0.978

GAPDHS

0.945

PNMAL2

0.941

GAPDH

0.941

PFKM

0.897

PFKP

0.893

PFKL

0.893

ENSG00000266953

0.886

Your Current Organism:

Homo sapiens

NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENO4	ENSG00000266953	ENSP00000345555	ENSP00000468690	enolase family member 4	Uncharacterized protein	0.886
ENO4	GAPDH	ENSP00000345555	ENSP00000229239	enolase family member 4	glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...]	0.941
ENO4	GAPDHS	ENSP00000345555	ENSP00000222286	enolase family member 4	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)	0.945
ENO4	PFKL	ENSP00000345555	ENSP00000269848	enolase family member 4	phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.893
ENO4	PFKM	ENSP00000345555	ENSP00000345771	enolase family member 4	phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.897
ENO4	PFKP	ENSP00000345555	ENSP00000370517	enolase family member 4	phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.893
ENO4	PGK1	ENSP00000345555	ENSP00000362413	enolase family member 4	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.985
ENO4	PGK2	ENSP00000345555	ENSP00000305995	enolase family member 4	phosphoglycerate kinase 2	0.983
ENO4	PNMAL2	ENSP00000345555	ENSP00000473036	enolase family member 4	paraneoplastic Ma antigen family-like 2	0.941
ENO4	TPI1	ENSP00000345555	ENSP00000229270	enolase family member 4	triosephosphate isomerase 1	0.978
ENSG00000266953	ENO4	ENSP00000468690	ENSP00000345555	Uncharacterized protein	enolase family member 4	0.886
ENSG00000266953	GAPDH	ENSP00000468690	ENSP00000229239	Uncharacterized protein	glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations throu [...]	0.689
ENSG00000266953	GAPDHS	ENSP00000468690	ENSP00000222286	Uncharacterized protein	glyceraldehyde-3-phosphate dehydrogenase, spermatogenic; May play an important role in regulating the switch between different pathways for energy production during spermiogenesis and in the spermatozoon. Required for sperm motility and male fertility (By similarity)	0.689
ENSG00000266953	PFKL	ENSP00000468690	ENSP00000269848	Uncharacterized protein	phosphofructokinase, liver; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.911
ENSG00000266953	PFKM	ENSP00000468690	ENSP00000345771	Uncharacterized protein	phosphofructokinase, muscle; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.911
ENSG00000266953	PFKP	ENSP00000468690	ENSP00000370517	Uncharacterized protein	phosphofructokinase, platelet; Catalyzes the third step of glycolysis, the phosphorylation of fructose-6-phosphate (F6P) by ATP to generate fructose-1,6-bisphosphate (FBP) and ADP	0.911
ENSG00000266953	PGK1	ENSP00000468690	ENSP00000362413	Uncharacterized protein	phosphoglycerate kinase 1; In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein)	0.956
ENSG00000266953	PGK2	ENSP00000468690	ENSP00000305995	Uncharacterized protein	phosphoglycerate kinase 2	0.956
ENSG00000266953	PNMAL2	ENSP00000468690	ENSP00000473036	Uncharacterized protein	paraneoplastic Ma antigen family-like 2	0.689
ENSG00000266953	TPI1	ENSP00000468690	ENSP00000229270	Uncharacterized protein	triosephosphate isomerase 1	0.964

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