node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CHIC1 | PDZRN3 | ENSP00000362601 | ENSP00000263666 | cysteine-rich hydrophobic domain 1 | PDZ domain containing ring finger 3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity) | 0.433 |
CHIC1 | ZCCHC13 | ENSP00000362601 | ENSP00000345633 | cysteine-rich hydrophobic domain 1 | zinc finger, CCHC domain containing 13 | 0.641 |
LRRC3DN | ZCCHC13 | ENSP00000471094 | ENSP00000345633 | LRRC3 downstream neighbor (non-protein coding) | zinc finger, CCHC domain containing 13 | 0.754 |
PAPD5 | ZCCHC13 | ENSP00000396995 | ENSP00000345633 | PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion | zinc finger, CCHC domain containing 13 | 0.666 |
PAPD7 | ZCCHC13 | ENSP00000230859 | ENSP00000345633 | PAP associated domain containing 7; DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation | zinc finger, CCHC domain containing 13 | 0.674 |
PDZRN3 | CHIC1 | ENSP00000263666 | ENSP00000362601 | PDZ domain containing ring finger 3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity) | cysteine-rich hydrophobic domain 1 | 0.433 |
PDZRN3 | ZCCHC13 | ENSP00000263666 | ENSP00000345633 | PDZ domain containing ring finger 3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity) | zinc finger, CCHC domain containing 13 | 0.591 |
PRMT1 | PRMT8 | ENSP00000406162 | ENSP00000372067 | protein arginine methyltransferase 1 | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | 0.814 |
PRMT1 | ZCCHC13 | ENSP00000406162 | ENSP00000345633 | protein arginine methyltransferase 1 | zinc finger, CCHC domain containing 13 | 0.653 |
PRMT2 | ZCCHC13 | ENSP00000347906 | ENSP00000345633 | protein arginine methyltransferase 2; Arginine methyltransferase that methylates the guanidino nitrogens of arginyl residues in proteins such as STAT3, FBL, histone H4. Acts as a coactivator (with NCOA2) of the androgen receptor (AR)-mediated transactivation. Acts as a coactivator (with estrogen) of estrogen receptor (ER)-mediated transactivation. Enhances PGR, PPARG, RARA-mediated transactivation. May inhibit NF-kappa-B transcription and promote apoptosis. Represses E2F1 transcriptional activity (in a RB1- dependent manner). May be involved in growth regulation | zinc finger, CCHC domain containing 13 | 0.653 |
PRMT3 | ZCCHC13 | ENSP00000331879 | ENSP00000345633 | protein arginine methyltransferase 3; Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues in some proteins | zinc finger, CCHC domain containing 13 | 0.653 |
PRMT6 | ZCCHC13 | ENSP00000359095 | ENSP00000345633 | protein arginine methyltransferase 6; Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA), with a strong preference for the formation of aDMA. Preferentially methylates arginyl residues present in a glycine and arginine-rich domain and displays preference for monomethylated substrates. Specifically mediates the asymmetric dimethylation of histone H3 ’Arg-2’ to form H3R2me2a. H3R2me2a represents a specific tag for epigenetic transcriptional repression and is mutually exclusive with methylation on hi [...] | zinc finger, CCHC domain containing 13 | 0.653 |
PRMT8 | PRMT1 | ENSP00000372067 | ENSP00000406162 | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | protein arginine methyltransferase 1 | 0.814 |
PRMT8 | ZCCHC13 | ENSP00000372067 | ENSP00000345633 | protein arginine methyltransferase 8; Membrane-associated arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and asymmetrical dimethylarginine (aDMA). Able to mono- and dimethylate EWS protein; however its precise role toward EWS remains unclear as it still interacts with fully methylated EWS | zinc finger, CCHC domain containing 13 | 0.653 |
ZCCHC13 | CHIC1 | ENSP00000345633 | ENSP00000362601 | zinc finger, CCHC domain containing 13 | cysteine-rich hydrophobic domain 1 | 0.641 |
ZCCHC13 | LRRC3DN | ENSP00000345633 | ENSP00000471094 | zinc finger, CCHC domain containing 13 | LRRC3 downstream neighbor (non-protein coding) | 0.754 |
ZCCHC13 | PAPD5 | ENSP00000345633 | ENSP00000396995 | zinc finger, CCHC domain containing 13 | PAP associated domain containing 5; Plays a role in replication-dependent histone mRNA degradation. May be involved in the terminal uridylation of mature histone mRNAs before their degradation is initiated. DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion | 0.666 |
ZCCHC13 | PAPD7 | ENSP00000345633 | ENSP00000230859 | zinc finger, CCHC domain containing 13 | PAP associated domain containing 7; DNA polymerase, probably involved in DNA repair. May play a role in sister chromatid cohesion. Does not play a role in replication-dependent histone mRNA degradation | 0.674 |
ZCCHC13 | PDZRN3 | ENSP00000345633 | ENSP00000263666 | zinc finger, CCHC domain containing 13 | PDZ domain containing ring finger 3; E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation (By similarity) | 0.591 |
ZCCHC13 | PRMT1 | ENSP00000345633 | ENSP00000406162 | zinc finger, CCHC domain containing 13 | protein arginine methyltransferase 1 | 0.653 |