node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CAMK2A | DLG1 | ENSP00000381412 | ENSP00000345731 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | discs, large homolog 1 (Drosophila) | 0.988 |
CAMK2A | DLGAP1 | ENSP00000381412 | ENSP00000316377 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | discs, large (Drosophila) homolog-associated protein 1 | 0.480 |
CAMK2A | EPB41L1 | ENSP00000381412 | ENSP00000337168 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | erythrocyte membrane protein band 4.1-like 1 | 0.903 |
CAMK2A | GRIA1 | ENSP00000381412 | ENSP00000285900 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | 0.930 |
CAMK2A | GRIN2A | ENSP00000381412 | ENSP00000332549 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.980 |
CAMK2A | MYO6 | ENSP00000381412 | ENSP00000358994 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] | 0.907 |
DLG1 | CAMK2A | ENSP00000345731 | ENSP00000381412 | discs, large homolog 1 (Drosophila) | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | 0.988 |
DLG1 | DLGAP1 | ENSP00000345731 | ENSP00000316377 | discs, large homolog 1 (Drosophila) | discs, large (Drosophila) homolog-associated protein 1 | 0.996 |
DLG1 | EPB41L1 | ENSP00000345731 | ENSP00000337168 | discs, large homolog 1 (Drosophila) | erythrocyte membrane protein band 4.1-like 1 | 0.993 |
DLG1 | GRIA1 | ENSP00000345731 | ENSP00000285900 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, AMPA 1; Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L- glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a [...] | 0.997 |
DLG1 | GRIN2A | ENSP00000345731 | ENSP00000332549 | discs, large homolog 1 (Drosophila) | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.998 |
DLG1 | KCNA3 | ENSP00000345731 | ENSP00000358784 | discs, large homolog 1 (Drosophila) | potassium voltage-gated channel, shaker-related subfamily, member 3; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.991 |
DLG1 | KCNA4 | ENSP00000345731 | ENSP00000328511 | discs, large homolog 1 (Drosophila) | potassium voltage-gated channel, shaker-related subfamily, member 4; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.993 |
DLG1 | KCNA5 | ENSP00000345731 | ENSP00000252321 | discs, large homolog 1 (Drosophila) | potassium voltage-gated channel, shaker-related subfamily, member 5; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. This channel displays rapid activation and slow inactivation. May play a role in regulating the secretion of insulin in normal pancreatic islets. Isoform 2 exhibits a voltage-dependent recovery from inacti [...] | 0.990 |
DLG1 | LCK | ENSP00000345731 | ENSP00000337825 | discs, large homolog 1 (Drosophila) | lymphocyte-specific protein tyrosine kinase | 0.992 |
DLG1 | MYO6 | ENSP00000345731 | ENSP00000358994 | discs, large homolog 1 (Drosophila) | myosin VI; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Myosin 6 is a reverse-direction motor protein that moves towards the minus-end of actin filaments. Has slow rate of actin-activated ADP release due to weak ATP binding. Functions in a variety of intracellular processes such as vesicular membrane trafficking and cell migration. Required for the structural integrity of the Golgi apparatus via the p53-dependent pro-survival pathway. Appears to be involved in a very early step of clathrin-mediated endocytosis in [...] | 0.998 |
DLGAP1 | CAMK2A | ENSP00000316377 | ENSP00000381412 | discs, large (Drosophila) homolog-associated protein 1 | calcium/calmodulin-dependent protein kinase II alpha; CaM-kinase II (CAMK2) is a prominent kinase in the central nervous system that may function in long-term potentiation and neurotransmitter release. Member of the NMDAR signaling complex in excitatory synapses it may regulate NMDAR-dependent potentiation of the AMPAR and synaptic plasticity (By similarity) | 0.480 |
DLGAP1 | DLG1 | ENSP00000316377 | ENSP00000345731 | discs, large (Drosophila) homolog-associated protein 1 | discs, large homolog 1 (Drosophila) | 0.996 |
DLGAP1 | GRIN2A | ENSP00000316377 | ENSP00000332549 | discs, large (Drosophila) homolog-associated protein 1 | glutamate receptor, ionotropic, N-methyl D-aspartate 2A; NMDA receptor subtype of glutamate-gated ion channels possesses high calcium permeability and voltage-dependent sensitivity to magnesium. Activation requires binding of agonist to both types of subunits | 0.720 |
DLGAP1 | KCNA4 | ENSP00000316377 | ENSP00000328511 | discs, large (Drosophila) homolog-associated protein 1 | potassium voltage-gated channel, shaker-related subfamily, member 4; Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient | 0.885 |