| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| NEDD4 | SCNN1A | ENSP00000345530 | ENSP00000353292 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.998 |
| NEDD4 | SCNN1B | ENSP00000345530 | ENSP00000345751 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
| NEDD4 | SCNN1G | ENSP00000345530 | ENSP00000300061 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, gamma subunit | 0.998 |
| NEDD4 | SGK1 | ENSP00000345530 | ENSP00000356832 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 1 | 0.993 |
| NEDD4 | UBC | ENSP00000345530 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
| NEDD4 | WNK4 | ENSP00000345530 | ENSP00000246914 | neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.468 |
| NEDD4L | RAF1 | ENSP00000383199 | ENSP00000251849 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | 0.959 |
| NEDD4L | SCNN1A | ENSP00000383199 | ENSP00000353292 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
| NEDD4L | SCNN1B | ENSP00000383199 | ENSP00000345751 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.999 |
| NEDD4L | SCNN1D | ENSP00000383199 | ENSP00000368411 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, delta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.907 |
| NEDD4L | SCNN1G | ENSP00000383199 | ENSP00000300061 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | sodium channel, non-voltage-gated 1, gamma subunit | 0.999 |
| NEDD4L | SGK1 | ENSP00000383199 | ENSP00000356832 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | serum/glucocorticoid regulated kinase 1 | 0.999 |
| NEDD4L | TSC22D3 | ENSP00000383199 | ENSP00000314655 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | TSC22 domain family, member 3; Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities (By similarity) | 0.975 |
| NEDD4L | UBC | ENSP00000383199 | ENSP00000344818 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | ubiquitin C | 0.999 |
| NEDD4L | WNK4 | ENSP00000383199 | ENSP00000246914 | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | WNK lysine deficient protein kinase 4; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively. Activates SCNN1A, SCNN1B, SCNN1D, SGK1, TRPV5 and TRPV6. Regulates the activity of the thiazide-sensitive Na-Cl cotransporter, SLC12A3, by phosphorylation which appears to prevent membrane trafficking of SLC12A3. Also inhibits the renal K(+) channel, KCNJ1, via a kinase-i [...] | 0.864 |
| RAF1 | NEDD4L | ENSP00000251849 | ENSP00000383199 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.959 |
| RAF1 | SCNN1A | ENSP00000251849 | ENSP00000353292 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | sodium channel, non-voltage-gated 1 alpha subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.900 |
| RAF1 | SCNN1B | ENSP00000251849 | ENSP00000345751 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | sodium channel, non-voltage-gated 1, beta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.955 |
| RAF1 | SCNN1D | ENSP00000251849 | ENSP00000368411 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | sodium channel, non-voltage-gated 1, delta subunit; Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception | 0.900 |
| RAF1 | SCNN1G | ENSP00000251849 | ENSP00000300061 | v-raf-1 murine leukemia viral oncogene homolog 1; Serine/threonine-protein kinase that acts as a regulatory link between the membrane-associated Ras GTPases and the MAPK/ERK cascade, and this critical regulatory link functions as a switch determining cell fate decisions including proliferation, differentiation, apoptosis, survival and oncogenic transformation. RAF1 activation initiates a mitogen-activated protein kinase (MAPK) cascade that comprises a sequential phosphorylation of the dual-specific MAPK kinases (MAP2K1/MEK1 and MAP2K2/MEK2) and the extracellular signal-regulated kinase [...] | sodium channel, non-voltage-gated 1, gamma subunit | 0.900 |
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