node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABAT | ALDH3A2 | ENSP00000268251 | ENSP00000345774 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.946 |
ABAT | EHHADH | ENSP00000268251 | ENSP00000231887 | 4-aminobutyrate aminotransferase; Catalyzes the conversion of gamma-aminobutyrate and L- beta-aminoisobutyrate to succinate semialdehyde and methylmalonate semialdehyde, respectively. Can also convert delta-aminovalerate and beta-alanine | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.949 |
ACSS1 | ACSS2 | ENSP00000316924 | ENSP00000253382 | acyl-CoA synthetase short-chain family member 1 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.907 |
ACSS1 | ADH1A | ENSP00000316924 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.549 |
ACSS1 | ADH1B | ENSP00000316924 | ENSP00000306606 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 1B (class I), beta polypeptide | 0.486 |
ACSS1 | ADH4 | ENSP00000316924 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.538 |
ACSS1 | ADH6 | ENSP00000316924 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 6 (class V) | 0.549 |
ACSS1 | ADH7 | ENSP00000316924 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 1 | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.549 |
ACSS1 | ALDH3A2 | ENSP00000316924 | ENSP00000345774 | acyl-CoA synthetase short-chain family member 1 | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.954 |
ACSS1 | EHHADH | ENSP00000316924 | ENSP00000231887 | acyl-CoA synthetase short-chain family member 1 | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.609 |
ACSS2 | ACSS1 | ENSP00000253382 | ENSP00000316924 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | acyl-CoA synthetase short-chain family member 1 | 0.907 |
ACSS2 | ADH1A | ENSP00000253382 | ENSP00000209668 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 1A (class I), alpha polypeptide | 0.428 |
ACSS2 | ADH4 | ENSP00000253382 | ENSP00000265512 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 4 (class II), pi polypeptide | 0.423 |
ACSS2 | ADH6 | ENSP00000253382 | ENSP00000378359 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 6 (class V) | 0.428 |
ACSS2 | ADH7 | ENSP00000253382 | ENSP00000420269 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide; Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism | 0.428 |
ACSS2 | ALDH3A2 | ENSP00000253382 | ENSP00000345774 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | aldehyde dehydrogenase 3 family, member A2; Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Active on a variety of saturated and unsaturated aliphatic aldehydes between 6 and 24 carbons in length. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid | 0.948 |
ACSS2 | EHHADH | ENSP00000253382 | ENSP00000231887 | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase | 0.643 |
ADH1A | ACSS1 | ENSP00000209668 | ENSP00000316924 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 1 | 0.549 |
ADH1A | ACSS2 | ENSP00000209668 | ENSP00000253382 | alcohol dehydrogenase 1A (class I), alpha polypeptide | acyl-CoA synthetase short-chain family member 2; Activates acetate so that it can be used for lipid synthesis or for energy generation | 0.428 |
ADH1A | AKR1B10 | ENSP00000209668 | ENSP00000352584 | alcohol dehydrogenase 1A (class I), alpha polypeptide | aldo-keto reductase family 1, member B10 (aldose reductase); Acts as all-trans-retinaldehyde reductase. Can efficiently reduce aliphatic and aromatic aldehydes, and is less active on hexoses (in vitro). May be responsible for detoxification of reactive aldehydes in the digested food before the nutrients are passed on to other organs | 0.400 |