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DSC3 DSC3 DSC2 DSC2 GGT6 GGT6 PKP3 PKP3 KLK6 KLK6 KLK11 KLK11 GJB4 GJB4 RPL34 RPL34 CLEC2A CLEC2A GJB5 GJB5 GJA4 GJA4
"GJB4" - gap junction protein, beta 4, 30.3kDa in Homo sapiens
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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protein of unknown 3D structure
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some 3D structure is known or predicted
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second shell of interactors
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Known Interactions
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Predicted Interactions
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protein homology
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Score
GJB4gap junction protein, beta 4, 30.3kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (266 aa)    
Predicted Functional Partners:
RPL34
ribosomal protein L34 (117 aa)
            score_image   0.860
CLEC2A
C-type lectin domain family 2, member A; Plays a role in modulating the extent of T-cell expansion. Enhances the expansion of TCR-stimulated T-cells by increasing their survival through enhanced expression of anti- apoptotic proteins. May modulate the capacity of T-cells to home to lymph nodes through SELL. Facilitates dedicated immune recognition of keratinocytes via interaction with its receptor KLRF2 by stimulating natural killer cell mediated cytotoxicity (174 aa)
            score_image   0.680
PKP3
plakophilin 3; May play a role in junctional plaques (797 aa)
            score_image   0.584
KLK11
kallikrein-related peptidase 11; Possible multifunctional protease. Efficiently cleaves ’bz-Phe-Arg-4-methylcoumaryl-7-amide’, a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues (282 aa)
            score_image   0.525
DSC2
desmocollin 2; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms (901 aa)
            score_image   0.488
DSC3
desmocollin 3; Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms (896 aa)
            score_image   0.487
GJB5
gap junction protein, beta 5, 31.1kDa; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell (273 aa)
      score_image   score_image score_image score_image 0.470
GGT6
gamma-glutamyltransferase 6; Cleaves glutathione conjugates (By similarity) (493 aa)
            score_image   0.463
KLK6
kallikrein-related peptidase 6; Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells [...] (244 aa)
            score_image   0.444
GJA4
gap junction protein, alpha 4, 37kDa (333 aa)
        score_image score_image score_image score_image 0.443
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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