node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BNC2 | SORCS1 | ENSP00000370047 | ENSP00000345964 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | sortilin-related VPS10 domain containing receptor 1 | 0.533 |
CELSR2 | COG2 | ENSP00000271332 | ENSP00000355629 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.512 |
CELSR2 | PSRC1 | ENSP00000271332 | ENSP00000358919 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | 0.813 |
CELSR2 | SORCS1 | ENSP00000271332 | ENSP00000345964 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | sortilin-related VPS10 domain containing receptor 1 | 0.681 |
CELSR2 | SORT1 | ENSP00000271332 | ENSP00000256637 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.757 |
COG2 | CELSR2 | ENSP00000355629 | ENSP00000271332 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.512 |
COG2 | PSRC1 | ENSP00000355629 | ENSP00000358919 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | 0.515 |
COG2 | SORCS1 | ENSP00000355629 | ENSP00000345964 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | sortilin-related VPS10 domain containing receptor 1 | 0.497 |
COG2 | SORT1 | ENSP00000355629 | ENSP00000256637 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.481 |
FURIN | SORCS1 | ENSP00000268171 | ENSP00000345964 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | sortilin-related VPS10 domain containing receptor 1 | 0.682 |
FURIN | SORT1 | ENSP00000268171 | ENSP00000256637 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.509 |
FURIN | VPS35 | ENSP00000268171 | ENSP00000299138 | furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif | vacuolar protein sorting 35 homolog (S. cerevisiae) | 0.467 |
LPIN3 | SORCS1 | ENSP00000362354 | ENSP00000345964 | lipin 3; Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity) | sortilin-related VPS10 domain containing receptor 1 | 0.523 |
PSRC1 | CELSR2 | ENSP00000358919 | ENSP00000271332 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.813 |
PSRC1 | COG2 | ENSP00000358919 | ENSP00000355629 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.515 |
PSRC1 | SORCS1 | ENSP00000358919 | ENSP00000345964 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | sortilin-related VPS10 domain containing receptor 1 | 0.681 |
PSRC1 | SORT1 | ENSP00000358919 | ENSP00000256637 | proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression | sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] | 0.757 |
SORCS1 | BNC2 | ENSP00000345964 | ENSP00000370047 | sortilin-related VPS10 domain containing receptor 1 | basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes | 0.533 |
SORCS1 | CELSR2 | ENSP00000345964 | ENSP00000271332 | sortilin-related VPS10 domain containing receptor 1 | cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation | 0.681 |
SORCS1 | COG2 | ENSP00000345964 | ENSP00000355629 | sortilin-related VPS10 domain containing receptor 1 | component of oligomeric golgi complex 2; Required for normal Golgi morphology and function | 0.497 |