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LPIN3 LPIN3 BNC2 BNC2 CELSR2 CELSR2 COG2 COG2 SORCS1 SORCS1 SORT1 SORT1 PSRC1 PSRC1 VPS26B VPS26B VPS35 VPS35 FURIN FURIN VPS26A VPS26A
"SORCS1" - sortilin-related VPS10 domain containing receptor 1 in Homo sapiens
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protein of unknown 3D structure
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Predicted Interactions
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SORCS1sortilin-related VPS10 domain containing receptor 1 (1198 aa)    
Predicted Functional Partners:
SORT1
sortilin 1; Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic diff [...] (831 aa)
        score_image   score_image score_image 0.702
FURIN
furin (paired basic amino acid cleaving enzyme); Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif (794 aa)
        score_image   score_image   0.682
PSRC1
proline/serine-rich coiled-coil 1; Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression (333 aa)
            score_image   0.681
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2 (flamingo homolog, Drosophila); Receptor that may have an important role in cell/cell signaling during nervous system formation (2923 aa)
            score_image   0.681
VPS26B
vacuolar protein sorting 26 homolog B (S. pombe); Probable component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network (By similarity) (336 aa)
            score_image   0.542
BNC2
basonuclin 2; Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes (1099 aa)
            score_image   0.533
LPIN3
lipin 3; Regulates fatty acid metabolism. Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis (By similarity) (851 aa)
            score_image   0.523
VPS26A
vacuolar protein sorting 26 homolog A (S. pombe); Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (327 aa)
            score_image   0.507
COG2
component of oligomeric golgi complex 2; Required for normal Golgi morphology and function (738 aa)
            score_image   0.497
VPS35
vacuolar protein sorting 35 homolog (S. cerevisiae) (796 aa)
            score_image   0.498
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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