node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRX | GNGT1 | ENSP00000221996 | ENSP00000248572 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | 0.449 |
CRX | PLEKHB1 | ENSP00000221996 | ENSP00000346127 | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.683 |
FUT7 | HECA | ENSP00000318142 | ENSP00000356630 | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | 0.770 |
FUT7 | PLEKHB1 | ENSP00000318142 | ENSP00000346127 | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.580 |
FUT7 | SELPLG | ENSP00000318142 | ENSP00000228463 | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.836 |
GNGT1 | CRX | ENSP00000248572 | ENSP00000221996 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.449 |
GNGT1 | PLEKHB1 | ENSP00000248572 | ENSP00000346127 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.576 |
HECA | FUT7 | ENSP00000356630 | ENSP00000318142 | headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | 0.770 |
HECA | PLEKHB1 | ENSP00000356630 | ENSP00000346127 | headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.506 |
HECA | SELPLG | ENSP00000356630 | ENSP00000228463 | headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.609 |
PLEK | PLEKHB1 | ENSP00000234313 | ENSP00000346127 | pleckstrin; Major protein kinase C substrate of platelets | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.511 |
PLEKHB1 | CRX | ENSP00000346127 | ENSP00000221996 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | cone-rod homeobox; Binds and transactivates the sequence 5’-TAATC[CA]-3’ which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, e.g. NRL and RX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors | 0.683 |
PLEKHB1 | FUT7 | ENSP00000346127 | ENSP00000318142 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | 0.580 |
PLEKHB1 | GNGT1 | ENSP00000346127 | ENSP00000248572 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein- effector interaction (By similarity) | 0.576 |
PLEKHB1 | HECA | ENSP00000346127 | ENSP00000356630 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | headcase homolog (Drosophila); May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs | 0.506 |
PLEKHB1 | PLEK | ENSP00000346127 | ENSP00000234313 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | pleckstrin; Major protein kinase C substrate of platelets | 0.511 |
PLEKHB1 | RAP1GDS1 | ENSP00000346127 | ENSP00000340454 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | RAP1, GTP-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein | 0.612 |
PLEKHB1 | SELPLG | ENSP00000346127 | ENSP00000228463 | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | 0.502 |
RAP1GDS1 | PLEKHB1 | ENSP00000340454 | ENSP00000346127 | RAP1, GTP-GDP dissociation stimulator 1; Stimulates GDP/GTP exchange reaction of a group of small GTP-binding proteins (G proteins) including Rap1a/Rap1b, RhoA, RhoB and KRas, by stimulating the dissociation of GDP from and the subsequent binding of GTP to each small G protein | pleckstrin homology domain containing, family B (evectins) member 1; Required for proper localization of retinogeniculate projections but not for eye-specific segregation (By similarity) | 0.612 |
SELPLG | FUT7 | ENSP00000228463 | ENSP00000318142 | selectin P ligand; A SLe(x)-type glycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. PSGL1 is critical for the initial leukocyte capture | fucosyltransferase 7 (alpha (1,3) fucosyltransferase); May catalyze alpha-1,3 glycosidic linkages involved in the expression of sialyl Lewis X antigens | 0.836 |