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STRINGSTRING
CANT1 CANT1 RNF19B RNF19B UPP2 UPP2 UPRT UPRT UCKL1 UCKL1 CDA CDA ITPA ITPA UMPS UMPS UPP1 UPP1 CMPK1 CMPK1 CMPK2 CMPK2
"UCKL1" - uridine-cytidine kinase 1-like 1 in Homo sapiens
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Predicted Interactions
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UCKL1uridine-cytidine kinase 1-like 1; May contribute to UTP accumulation needed for blast transformation and proliferation (548 aa)    
Predicted Functional Partners:
UPRT
uracil phosphoribosyltransferase (FUR1) homolog (S. cerevisiae) (309 aa)
score_image   score_image score_image score_image score_image score_image score_image 0.996
RNF19B
ring finger protein 19B; E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as UCKL1. Involved in the cytolytic activity of natural killer cells and cytotoxic T-cells (732 aa)
        score_image   score_image   0.987
UMPS
uridine monophosphate synthetase (480 aa)
      score_image score_image score_image score_image   0.982
CDA
cytidine deaminase; This enzyme scavenge exogenous and endogenous cytidine and 2’-deoxycytidine for UMP synthesis (146 aa)
score_image     score_image   score_image score_image   0.962
UPP2
uridine phosphorylase 2; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(’)-deoxyuridine as substrates (374 aa)
          score_image score_image   0.935
UPP1
uridine phosphorylase 1; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis (310 aa)
          score_image score_image   0.935
ITPA
inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (194 aa)
score_image     score_image   score_image score_image   0.928
CMPK1
cytidine monophosphate (UMP-CMP) kinase 1, cytosolic; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors (228 aa)
score_image     score_image   score_image score_image   0.924
CANT1
calcium activated nucleotidase 1; Calcium-dependent nucleotidase with a preference for UDP. The order of activity with different substrates is UDP > GDP > UTP > GTP. Has very low activity towards ADP and even lower activity towards ATP. Does not hydrolyze AMP and GMP. Involved in proteoglycan synthesis (401 aa)
          score_image score_image   0.916
CMPK2
cytidine monophosphate (UMP-CMP) kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Efficacy is highest for dUMP followed by dCMP; CMP and UMP are poor substrates. May be involved in mtDNA depletion caused by long term treatment with ddC or other pyrimidine analogs (449 aa)
          score_image score_image   0.916
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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