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CDKN2B CDKN2B TNFRSF19 TNFRSF19 COX7B2 COX7B2 MECOM MECOM BPI BPI WDR65 WDR65 BPIFA1 BPIFA1 SMAD6 SMAD6 PLTP PLTP BPIFB2 BPIFB2 CETP CETP
"BPIFA1" - BPI fold containing family A, member 1 in Homo sapiens
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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small protein node
small nodes:
protein of unknown 3D structure
large protein node
large nodes:
some 3D structure is known or predicted
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colored nodes:
query proteins and first shell of interactors
non-colored protein node
white nodes:
second shell of interactors
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
database edge
from curated databases
experiment edge
experimentally determined
Predicted Interactions
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gene neighborhood
fusion edge
gene fusions
cooccurrence edge
gene co-occurrence
Others
textmining edge
textmining
coexpression edge
co-expression
homology edge
protein homology
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Score
BPIFA1BPI fold containing family A, member 1; May be involved in the airway inflammatory response after exposure to irritants. May be associated with tumor progression. May play a role in innate immune responses of the upper airways (256 aa)    
Predicted Functional Partners:
COX7B2
cytochrome c oxidase subunit VIIb2; This protein is one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport (81 aa)
            score_image   0.811
PLTP
phospholipid transfer protein; Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Essential for the transfer of excess surface lipids from triglyceride-rich lipoproteins to HDL, thereby facilitating the formation of smaller lipoprotein remnants, contributing to the formation of LDL, and assisting in the maturation of HDL particles. PLTP also plays a key role in the uptake of cholesterol from peripheral cells and tissues that [...] (493 aa)
            score_image   0.748
CETP
cholesteryl ester transfer protein, plasma; Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol (493 aa)
            score_image   0.660
MECOM
MDS1 and EVI1 complex locus (1116 aa)
            score_image   0.606
BPI
bactericidal/permeability-increasing protein (487 aa)
            score_image   0.569
TNFRSF19
tumor necrosis factor receptor superfamily, member 19; Can mediate activation of JNK and NF-kappa-B. May promote caspase-independent cell death (423 aa)
            score_image   0.563
SMAD6
SMAD family member 6; Acts as a mediator of TGF-beta and BMP antiflammatory activity. Suppresses IL1R-TLR signaling through its direct interaction with PEL1, preventing NF-kappa-B activation, nuclear transport and NF-kappa-B-mediated expression of proinflammatory genes. May block the BMP-SMAD1 signaling pathway by competing with SMAD4 for receptor-activated SMAD1-binding. Binds to regulatory elements in target promoter regions (496 aa)
        score_image       0.556
BPIFB2
BPI fold containing family B, member 2 (458 aa)
            score_image   0.535
CDKN2B
cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4); Interacts strongly with CDK4 and CDK6. Potent inhibitor. Potential effector of TGF-beta induced cell cycle arrest (138 aa)
            score_image   0.489
WDR65
WD repeat domain 65 (698 aa)
            score_image   0.472
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
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