node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
APBA2 | APBB3 | ENSP00000453144 | ENSP00000346378 | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | 0.550 |
APBA2 | APLP1 | ENSP00000453144 | ENSP00000221891 | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | amyloid beta (A4) precursor-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I | 0.416 |
APBA2 | APLP2 | ENSP00000453144 | ENSP00000263574 | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.863 |
APBA2 | APP | ENSP00000453144 | ENSP00000284981 | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | amyloid beta (A4) precursor protein | 0.989 |
APBA3 | APBB3 | ENSP00000315136 | ENSP00000346378 | amyloid beta (A4) precursor protein-binding, family A, member 3; May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | 0.781 |
APBA3 | APLP2 | ENSP00000315136 | ENSP00000263574 | amyloid beta (A4) precursor protein-binding, family A, member 3; May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.928 |
APBA3 | APP | ENSP00000315136 | ENSP00000284981 | amyloid beta (A4) precursor protein-binding, family A, member 3; May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN | amyloid beta (A4) precursor protein | 0.993 |
APBB3 | APBA2 | ENSP00000346378 | ENSP00000453144 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | 0.550 |
APBB3 | APBA3 | ENSP00000346378 | ENSP00000315136 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor protein-binding, family A, member 3; May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP. May enhance the activity of HIF1A in macrophages by inhibiting the activity of HIF1AN | 0.781 |
APBB3 | APLP1 | ENSP00000346378 | ENSP00000221891 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I | 0.832 |
APBB3 | APLP2 | ENSP00000346378 | ENSP00000263574 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.963 |
APBB3 | APP | ENSP00000346378 | ENSP00000284981 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | amyloid beta (A4) precursor protein | 0.987 |
APBB3 | HIST1H4G | ENSP00000346378 | ENSP00000244537 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | histone cluster 1, H4g; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity) | 0.453 |
APBB3 | KAT5 | ENSP00000346378 | ENSP00000340330 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | K(lysine) acetyltransferase 5 | 0.450 |
APBB3 | NAE1 | ENSP00000346378 | ENSP00000290810 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | NEDD8 activating enzyme E1 subunit 1; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation | 0.636 |
APBB3 | P2RX2 | ENSP00000346378 | ENSP00000343339 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | purinergic receptor P2X, ligand-gated ion channel, 2 | 0.595 |
APBB3 | PID1 | ENSP00000346378 | ENSP00000375907 | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | phosphotyrosine interaction domain containing 1; Increases proliferation of preadipocytes without affecting adipocytic differentiation | 0.650 |
APLP1 | APBA2 | ENSP00000221891 | ENSP00000453144 | amyloid beta (A4) precursor-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I | amyloid beta (A4) precursor protein-binding, family A, member 2; Putative function in synaptic vesicle exocytosis by binding to STXBP1, an essential component of the synaptic vesicle exocytotic machinery. May modulate processing of the beta-amyloid precursor protein (APP) and hence formation of beta-APP | 0.416 |
APLP1 | APBB3 | ENSP00000221891 | ENSP00000346378 | amyloid beta (A4) precursor-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I | amyloid beta (A4) precursor protein-binding, family B, member 3; May modulate the internalization of beta-amyloid precursor protein | 0.832 |
APLP1 | APLP2 | ENSP00000221891 | ENSP00000263574 | amyloid beta (A4) precursor-like protein 1; May play a role in postsynaptic function. The C-terminal gamma-secretase processed fragment, ALID1, activates transcription activation through APBB1 (Fe65) binding (By similarity). Couples to JIP signal transduction through C-terminal binding. May interact with cellular G-protein signaling pathways. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I | amyloid beta (A4) precursor-like protein 2; May play a role in the regulation of hemostasis. The soluble form may have inhibitory properties towards coagulation factors. May interact with cellular G-protein signaling pathways. May bind to the DNA 5’-GTCACATG-3’(CDEI box). Inhibits trypsin, chymotrypsin, plasmin, factor XIA and plasma and glandular kallikrein. Modulates the Cu/Zn nitric oxide-catalyzed autodegradation of GPC1 heparan sulfate side chains in fibroblasts (By similarity) | 0.619 |