Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Size
small nodes:
protein of unknown 3D structure
protein of unknown 3D structure
large nodes:
some 3D structure is known or predicted
some 3D structure is known or predicted
Node Color
colored nodes:
query proteins and first shell of interactors
query proteins and first shell of interactors
white nodes:
second shell of interactors
second shell of interactors
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Your Input:
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Neighborhood |
Gene Fusion |
Cooccurence |
Coexpression |
Experiments |
Databases |
Textmining |
[Homology] |
Score |
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 | RNH1 | ribonuclease/angiogenin inhibitor 1; Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (461 aa) | ||||||||||||
Predicted Functional Partners:
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 | ANG | angiogenin, ribonuclease, RNase A family, 5; Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo (147 aa) |
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0.997 | ||||||||
 | RNASE1 | ribonuclease, RNase A family, 1 (pancreatic) (156 aa) |
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0.982 | |||||||||
 | UBC | ubiquitin C (685 aa) |
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0.976 | |||||||||
 | RNASE2 | ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin); This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities (161 aa) |
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0.920 | |||||||||
 | FBXO38 | F-box protein 38; Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. May coactivate KLF7, but does not seem to promote KLF7 ubiquitination (By similarity) (1188 aa) |
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0.813 | ||||||||||
 | CD36 | CD36 molecule (thrombospondin receptor) (472 aa) |
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0.795 | ||||||||||
 | SCARB1 | scavenger receptor class B, member 1; Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells. Probable receptor for HDL, located in particular region of the plasma membrane, called caveolae. Facilitates the flux of free and esterified cholesterol between the cell surface and extracellular donors and acceptors, such as HDL and to a lesser extent, apoB-containing lipoproteins and modified lipoproteins. Probably involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity. Receptor for h [...] (509 aa) |
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0.794 | ||||||||||
 | FBXO39 | F-box protein 39; Substrate-recognition component of the SCF (SKP1-CUL1-F- box protein)-type E3 ubiquitin ligase complex (By similarity) (442 aa) |
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0.760 | ||||||||||
 | DSTN | destrin (actin depolymerizing factor); Actin-depolymerizing protein. Severs actin filaments (F- actin) and binds to actin monomers (G-actin). Acts in a pH- independent manner (165 aa) |
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0.749 | |||||||||
 | G3BP2 | GTPase activating protein (SH3 domain) binding protein 2; Probable scaffold protein that may be involved in mRNA transport (Potential) (482 aa) |
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0.740 | ||||||||||
Your Current Organism:
Homo sapiens
NCBI taxonomy Id: 9606
Other names: H. sapiens, Homo, Homo sapiens, human, man
Other names: H. sapiens, Homo, Homo sapiens, human, man
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