node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AHR | CCND1 | ENSP00000242057 | ENSP00000227507 | aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.414 |
AHR | SMOC2 | ENSP00000242057 | ENSP00000346537 | aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues | SPARC related modular calcium binding 2 | 0.817 |
CABP2 | SMOC2 | ENSP00000294288 | ENSP00000346537 | calcium binding protein 2 | SPARC related modular calcium binding 2 | 0.871 |
CCND1 | AHR | ENSP00000227507 | ENSP00000242057 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues | 0.414 |
CCND1 | SMOC2 | ENSP00000227507 | ENSP00000346537 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | SPARC related modular calcium binding 2 | 0.820 |
FRMD1 | SMOC2 | ENSP00000283309 | ENSP00000346537 | FERM domain containing 1 | SPARC related modular calcium binding 2 | 0.485 |
FRMD1 | TCTE3 | ENSP00000283309 | ENSP00000355736 | FERM domain containing 1 | t-complex-associated-testis-expressed 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity) | 0.487 |
PHF10 | SMOC2 | ENSP00000341805 | ENSP00000346537 | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] | SPARC related modular calcium binding 2 | 0.520 |
PHF10 | TCTE3 | ENSP00000341805 | ENSP00000355736 | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] | t-complex-associated-testis-expressed 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity) | 0.768 |
SMOC2 | AHR | ENSP00000346537 | ENSP00000242057 | SPARC related modular calcium binding 2 | aryl hydrocarbon receptor; Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates. Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons. Involved in cell-cycle regulation. Likely to play an important role in the development and maturation of many tissues | 0.817 |
SMOC2 | CABP2 | ENSP00000346537 | ENSP00000294288 | SPARC related modular calcium binding 2 | calcium binding protein 2 | 0.871 |
SMOC2 | CCND1 | ENSP00000346537 | ENSP00000227507 | SPARC related modular calcium binding 2 | cyclin D1; Regulatory component of the cyclin D1-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate [...] | 0.820 |
SMOC2 | FRMD1 | ENSP00000346537 | ENSP00000283309 | SPARC related modular calcium binding 2 | FERM domain containing 1 | 0.485 |
SMOC2 | PHF10 | ENSP00000346537 | ENSP00000341805 | SPARC related modular calcium binding 2 | PHD finger protein 10; Involved in transcription activity regulation by chromatin remodeling. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. [...] | 0.520 |
SMOC2 | SRPX2 | ENSP00000346537 | ENSP00000362095 | SPARC related modular calcium binding 2 | sushi-repeat containing protein, X-linked 2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development | 0.489 |
SMOC2 | TCTE3 | ENSP00000346537 | ENSP00000355736 | SPARC related modular calcium binding 2 | t-complex-associated-testis-expressed 3; May be an accessory component of axonemal dynein and cytoplasmic dynein 1. Candidate for involvement in male sterility (By similarity) | 0.501 |
SMOC2 | TSTD1 | ENSP00000346537 | ENSP00000388293 | SPARC related modular calcium binding 2 | thiosulfate sulfurtransferase (rhodanese)-like domain containing 1; Possible role in tumorigenesis | 0.538 |
SMOC2 | WDR44 | ENSP00000346537 | ENSP00000254029 | SPARC related modular calcium binding 2 | WD repeat domain 44 | 0.485 |
SMOC2 | ZDHHC22 | ENSP00000346537 | ENSP00000318222 | SPARC related modular calcium binding 2 | zinc finger, DHHC-type containing 22 | 0.597 |
SRPX2 | SMOC2 | ENSP00000362095 | ENSP00000346537 | sushi-repeat containing protein, X-linked 2; Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion in cancer cells. Increases the phosphorylation levels of FAK. May have a role in the perisylvian region, critical for language and cognitive development | SPARC related modular calcium binding 2 | 0.489 |